2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related
  4. PY109

PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC50 values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis.

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PY109

PY109 Chemical Structure

CAS No. : 2378039-23-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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PY109 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

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Description

PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC50 values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis[1].

IC50 & Target[1]

CYP1A1

 

IL-22

 

IL-17A

 

Molecular Weight

290.24

Formula

C15H9F3N2O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CNC2=C1C=CC=C2)C3=NC(C(F)(F)F)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (344.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4454 mL 17.2271 mL 34.4542 mL
5 mM 0.6891 mL 3.4454 mL 6.8908 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4454 mL 17.2271 mL 34.4542 mL 86.1356 mL
5 mM 0.6891 mL 3.4454 mL 6.8908 mL 17.2271 mL
10 mM 0.3445 mL 1.7227 mL 3.4454 mL 8.6136 mL
15 mM 0.2297 mL 1.1485 mL 2.2969 mL 5.7424 mL
20 mM 0.1723 mL 0.8614 mL 1.7227 mL 4.3068 mL
25 mM 0.1378 mL 0.6891 mL 1.3782 mL 3.4454 mL
30 mM 0.1148 mL 0.5742 mL 1.1485 mL 2.8712 mL
40 mM 0.0861 mL 0.4307 mL 0.8614 mL 2.1534 mL
50 mM 0.0689 mL 0.3445 mL 0.6891 mL 1.7227 mL
60 mM 0.0574 mL 0.2871 mL 0.5742 mL 1.4356 mL
80 mM 0.0431 mL 0.2153 mL 0.4307 mL 1.0767 mL
100 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.8614 mL
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PY109 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PY1092378039-23-5PY 109PY-109Aryl Hydrocarbon ReceptorCytochrome P450Interleukin RelatedAhRCYPsILAHR agonistinflammatory bowel diseaseIL-22rational drug designDSS-induced colitispharmacokineticslymphocyte modulationmucosal healingInhibitorinhibitorinhibit

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