2378039-23-5
2378039-23-5
Chemical Structure
PY109
- CAS No.: 2378039-23-5
- Formula:C15H9F3N2O
- Molecular Weight:290.24
IUPAC Name: 5-phenyl-3-(pyridin-4-yl)pyrazin-2-amine
InChIKey: LANJLFOCGPBZLQ-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=C1C=CC=C2)C3=NC(C(F)(F)F)=CC=C3
Biological Activity: PY109 is an orally active AHR agonist with anti-inflammatory activity. PY109 promotes the production of the pro-inflammatory cytokines IL‑17A and IL‑22, and reduces disease severity in a mouse colitis model. PY109 can be used for colitis-related research[1][2].
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PY109 | 99.15% | PY109 is an orally active AHR agonist with anti-inflammatory activity. PY109 promotes the production of the pro-inflammatory cytokines IL‑17A and IL‑22, and reduces disease severity in a mouse colitis model. PY109 can be used for colitis-related research. | ||||||||||||||||||||
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References
- [1]. Zhu Z, et al. AHR-Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg-Mediated Macrophage Efferocytosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2026 Sep 06.
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[2]. Dvořák Z. Drug Mimicry: Promiscuous Receptors PXR and AhR, and Microbial Metabolite Interactions in the Intestine. Trends in Pharmacological Sciences, 2020, 41(12): 900-908.
