IL-17 modulator 4 sulfate
IL-17 modulator 4 sulfate is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 sulfate is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome.
For research use only. We do not sell to patients.
- CAS No.: 2446806-90-0
- Formula: C27H34N6O2.2/3H2O4S
- Molecular Weight:621.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-17 |
IL-17 modulator 4 sulfate (Compound 23) is a modulator for IL-17A protein-protein interaction, that stabilizes the conformation of IL-17A by binding to the central pocket of the IL-17A dimer, making it unable to effectively bind to the IL-17RA receptor, thereby inhibiting the IL-17A-mediated signaling pathway[3].
IL-17 modulator 4 sulfate (Compound 23) inhibits glycosylated IL-17A and TNFα costimulated IL-8 secretion in HEKa cell with an EC50 of 14 nM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2446806-90-0
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Molecular Weight 621.70
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Formula C27H34N6O2.2/3H2O4S
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SMILES
O=S(O)(O)=O.O=C(C1=CC=NN1C(C)C)N[C@H](C(NC2=CC=C(C3=C(C)NN=C3C)C=C2)=O)C(C4CC4)C5CC5.[2/3]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IL-17 modulator 4 sulfate Related Classifications
HY-141692A Related Classifications
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