1. Metabolic Enzyme/Protease
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  3. FM26

FM26 

Cat. No.: HY-133128
Handling Instructions

FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells.

For research use only. We do not sell to patients.

FM26 Chemical Structure

FM26 Chemical Structure

CAS No. : 2407981-35-3

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Description

FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].

IC50 & Target

IC50: 264 nM (RORγt)[1]

In Vitro

FM26 (compound 25; 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells[1].

Molecular Weight

461.82

Formula

C₂₂H₁₅ClF₃N₃O₃

CAS No.

2407981-35-3

SMILES

O=C(O)C1=CC=C(NCC2=C(C3=CNC=C3)ON=C2C4=C(C(F)(F)F)C=CC=C4Cl)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FM26FM 26FM-26RORRAR-related orphan receptorallostericRORγtinverseisoxazolechemotypeIL-17amRNAEL4cellsInhibitorinhibitorinhibit

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