Anti-Mouse/Rat IL-17A Antibody (17F3) 

Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1κ type antibody inhibitor, targeting to mouse and rat IL-17A. Anti-Mouse IL-17A Antibody (17F3) can neutralize IL-17. Anti-Mouse/Rat IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes^[1][2][3].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

Mouse

IL-17A

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat IL-17A Antibody (17F3) (100 μg, i.p., every other day for 11 days) shows potent anti-infective effective in M.intracellulare-infected mice models^[1].
Anti-Mouse/Rat IL-17A Antibody (17F3) (0.5 mg/dose, i.p., 3 times/week) reduces autoimmune infiltrates in immune checkpoint inhibitor (ICI)-treated mice models^[2].
Anti-Mouse/Rat IL-17A Antibody (17F3) (200 μg, i.p., twice weekly until week 12) is protective against diabetic nephropathy in streptozotocin (HY-13753)-induced diabetic mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

16171  [NCBI]

Q62386

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse/Rat IL-17A Antibody (17F3)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Immobilized IL-17A Protein, Mouse (HEK293, His, HY-P70753) can bind Anti-Mouse IL-17A Antibody (17F3). The EC₅₀ for this effect is 13 ng/mL.

• [1]. Jung BG, et al. Early IL-17A production helps establish Mycobacterium intracellulare infection in mice. PLoS Pathog. 2022 Apr 1;18(4):e1010454.  [Content Brief]

  [2]. Lechner MG, et al. Inhibition of IL-17A Protects against Thyroid Immune-Related Adverse Events while Preserving Checkpoint Inhibitor Antitumor Efficacy. J Immunol. 2022 Aug 15;209(4):696-709.  [Content Brief]

  [3]. Ma J, et al. Interleukin 17A promotes diabetic kidney injury. Sci Rep. 2019 Feb 19;9(1):2264.  [Content Brief]