2. Gene
  3. Il17a - interleukin 17A Gene

Il17a - interleukin 17A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Il17; Ctla8; IL-17; Ctla-8; IL-17A

Gene ID: 16171 | Gene type: protein coding

About Il17a

Chromosome 1: 20,801,129-20,804,720 forward strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 97 orthologues, 5 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

Il17a Products(1)

mRNA Protein Name
NM_010552.3 NP_034682.1 interleukin-17A precursor

Il17a Protein Structure

IL17

IL17: pfam06083 (71 - 149)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

interleukin-17A

cytotoxic T-lymphocyte-associated antigen 8

Recombinant Il17a Proteins

Cat. No. Product Name Accession Purity
HY-P7372 IL-17A Protein, Mouse (CHO) Q62386 (A26-A158) ≥95%
HY-P70753 IL-17A Protein, Mouse (HEK293, His) Q62386 (T22-A158) ≥95%
HY-P73174 IL-17A Protein, Mouse Q62386 (T22-A158) ≥95%
HY-P77707 IL-17A-17F Heterodimer Protein, Mouse (HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7 (R29-A161) ≥95%
HY-P77708 IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7-1 (R29-A161) ≥95%
HY-P78158 IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62386 (A26-A158) ≥95%
HY-P78320 IL-17A Protein, Mouse (HEK293, His-Avi) Q62386 (A26-A158) ≥95%
HY-P700194AF Animal-Free IL-17A Protein, Mouse (His) Q62386 (A26-A158) ≥95%

Related Agents

Approval
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9927 Secukinumab Inhibitor ≥99.20% Unkown
HY-P9924 Ixekizumab Inhibitor 98.90% Unkown
HY-P99280 Bimekizumab Antagonist 95.00% Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-103637A Vimirogant hydrochloride Inhibitor 98.39% Phase 2
HY-103637 Vimirogant Inhibitor / Phase 2
HY-107390A AX-024 hydrochloride Inhibitor 99.75% Phase 1
HY-152851 Izumerogant Agonist / Phase 1
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99515 Xeligekimab Inhibitor 95.00% Phase 3
HY-P99652 Gumokimab Inhibitor / Phase 3
HY-P99563 Tibulizumab Inhibitor / Phase 3
HY-P99397 Sonelokimab Inhibitor 99.90% Phase 2
HY-P99940 Remtolumab Inhibitor 99.24% Phase 2
Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15826 SGC-CBP30 Inhibitor 99.83% Unkown
HY-139206 LY3509754 Inhibitor 99.65% Unkown
HY-101913 IL-17A antagonist 1 Antagonist 99.74% Unkown
HY-107390 AX-024 Inhibitor 99.29% Yes
HY-145430 IL-17A modulator-1 Modulator 99.01% Unkown
HY-139780 JNJ-61803534 Inhibitor 99.88% Unkown
HY-145429 IL-17A modulator-2 Modulator 99.07% Unkown
HY-101915 IL-17A antagonist 3 Antagonist 98.55% Unkown
HY-119464 MRL-871 Agonist 98.18% Unkown
HY-133552 RORγt Inverse agonist 10 Antagonist 99.13% Unkown
HY-P3450 Erepdekinra Antagonist 98.60% Unkown
HY-128353 ROR agonist-1 Antagonist / Unkown
HY-126252 A-9758 Inhibitor / Unkown
HY-130243 RORγt Inverse agonist 6 Antagonist 98.97% Unkown
HY-133128 FM26 Antagonist / Unkown
HY-139686 IL-17A inhibitor 2 Inhibitor / Unkown
HY-142939 RORγt modulator 4 Modulator / Unkown
HY-148272 IL-17A modulator-3 Modulator / Unkown
HY-153276 Androgen receptor-IN-5 Inhibitor / Unkown
HY-155243 12R-LOX-IN-1 Inhibitor / Unkown
HY-158159 IL17A-IN-1 Inhibitor / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / Unkown
HY-N11768 4-Methoxylonchocarpin Inhibitor / Unkown
HY-RS06695 IL17A Human Pre-designed siRNA Set A / Unkown
HY-RS06696 Il17a Mouse Pre-designed siRNA Set A / Unkown
HY-RS06697 Il17a Rat Pre-designed siRNA Set A / Unkown
HY-155244 12R-LOX-IN-2 Inhibitor / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9927A Anti-Human IL-17A Antagonist 96.32% Unkown
HY-P99310 Perakizumab Inhibitor 99.79% Unkown
HY-P99335 Vunakizumab 95.00% Unkown
HY-P99424 Afasevikumab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il17a NCBI NCBI:3605
Canis familiaris Il17a NCBI NCBI:481837
Macaca fascicularis Il17a NCBI NCBI:102119976
Susscrofa domestica Il17a NCBI
Leporidae Il17a NCBI
Rattus norvegicus Il17a NCBI NCBI:301289
Macaca mulatta Il17a NCBI NCBI:708123