Il17a - interleukin 17A Gene

Also Known as Il17; Ctla8; IL-17; Ctla-8; IL-17A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16171

About Il17a

Chromosome 1: 20,801,129-20,804,720 forward strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 97 orthologues, 5 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with Other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

Il17a Products (1)

mRNA Protein Name
NM_010552.3 NP_034682.1 interleukin-17A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
22727489 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18025225 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
18025225 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
18025225 MGI
Biological Process GO Annotation Evidence References Source
involved in Notch signaling pathway IDA
IDA: Inferred from direct assay
28561022 MGI
acts upstream of or within cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
19666510 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
19144317 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
20364087 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
19144317 MGI
involved in defense response to fungus IMP
IMP: Inferred from mutant phenotype
20554964 MGI
involved in gene expression IDA
IDA: Inferred from direct assay
31164412 MGI
involved in granulocyte migration IGI
IGI: Inferred from genetic interaction
24026300 MGI
involved in intestinal epithelial structure maintenance IMP
IMP: Inferred from mutant phenotype
26431948 MGI
involved in keratinocyte differentiation IDA
IDA: Inferred from direct assay
31164412 MGI
involved in keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
31164412 MGI
involved in negative regulation of inflammatory response to wounding IDA
IDA: Inferred from direct assay
27830702 MGI
involved in positive regulation of antimicrobial peptide production IDA
IDA: Inferred from direct assay
19144317 MGI
involved in positive regulation of bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
26431948 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production IDA
IDA: Inferred from direct assay
18025225 MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
17982105 MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response IGI
IGI: Inferred from genetic interaction
16785495 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
20554964 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16982811 MGI
involved in response to wounding IDA
IDA: Inferred from direct assay
22727489 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18792410 MGI
is active in extracellular space IDA
IDA: Inferred from direct assay
22727489 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
16239543 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il17a Protein Structure

IL17

IL17: pfam06083 (71 - 149)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

interleukin-17A

  • cytotoxic T-lymphocyte-associated antigen 8

Recombinant Il17a Proteins

Cat. No. Product Name Accession Purity
HY-P7372 IL-17A Protein, Mouse (CHO) Q62386 (A26-A158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70753 IL-17A Protein, Mouse (HEK293, His) Q62386 (T22-A158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77707 IL-17A/F Heterodimer Protein, Mouse (HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7 (R29-A161) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77708 IL-17A/F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7-1 (R29-A161) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78158 IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62386 (A26-A158) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700194AF Animal-Free IL-17A Protein, Mouse (His) Q62386 (A26-A158) ≥ 95%, as determined by reducing SDS-PAGE.

Il17a Antibodies

Cat. No. Product Name Application Reactivity
HY-P81114 IL17A Antibody WB, ELISA, IHC-P, IHC-F, ICC/IF Mouse, Rat,

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99280 Bimekizumab Antagonist 99.52% Unkown
HY-P9927 Secukinumab Inhibitor ≥99.20% Unkown
HY-P9924 Ixekizumab Inhibitor 99.00% Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-177129 Simepdekinra Antagonist 99.05% Phase 2
HY-155830 Morcamilast Inhibitor 98.92% Phase 2
HY-153780 Navepdekinra Inhibitor 98.58% Phase 2
HY-103637 Vimirogant Inhibitor / Phase 2
HY-139206 LY3509754 Inhibitor 99.35% Phase 1
HY-107390 AX-024 Inhibitor 99.73% Phase 1
HY-107390A AX-024 hydrochloride Inhibitor 99.23% Phase 1
HY-139780 JNJ-61803534 Inhibitor 99.84% Phase 1
Inhibitory Antibodies (13)
Cat. No. Product Name Effect
Purity Phase
HY-P99335 Vunakizumab Inhibitor 95.00% Phase 4
HY-P99515 Xeligekimab Inhibitor 95.00% Phase 4
HY-P99563 Tibulizumab Inhibitor 98.86% Phase 3
HY-P99652 Gumokimab Inhibitor 98.95% Phase 3
HY-P99754 Netakimab Inhibitor 95.00% Phase 3
HY-P990761 Roconkibart 95.15% Phase 3
HY-P991595 HB-0017 Inhibitor / Phase 3
HY-P990741 Galvokimig 98.74% Phase 2
HY-P991091 COVA322 Inhibitor / Phase 2
HY-P991261 CJM-112 Inhibitor 99.65% Phase 2
HY-P991260 CNTO-6785 Inhibitor / Phase 2
HY-P991725 Velvakiment Inhibitor / Phase 2
HY-P991263 SCH-900117 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (58)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15826 SGC-CBP30 Inhibitor 99.83% Unkown
HY-P1924 IRBP(651-670) human, mouse Activator 99.64% Unkown
HY-101913 IL-17A antagonist 1 Antagonist 99.74% Unkown
HY-141692 IL-17 modulator 4 Modulator 98.19% Unkown
HY-P3450 Erepdekinra Antagonist 98.63% Unkown
HY-N0902 Dihydrosanguinarine Inhibitor 99.98% Unkown
HY-N3029 Noreugenin Inhibitor 99.42% Unkown
HY-119464 MRL-871 Agonist 99.11% Unkown
HY-147128 PY109 Agonist 99.15% Unkown
HY-101915 IL-17A antagonist 3 Antagonist 99.25% Unkown
HY-141692B (R)-IL-17 modulator 4 99.56% Unkown
HY-145429 IL-17A modulator-2 Modulator 98.44% Unkown
HY-145430 IL-17A modulator-1 Modulator 98.80% Unkown
HY-169853 M351-0056 99.48% Unkown
HY-183326 Isosorbide di-(methyl fumarate) Activator 99.87% Unkown
HY-103637A Vimirogant hydrochloride Inhibitor 98.39% Unkown
HY-139686 IL-17A inhibitor 2 Inhibitor 99.86% Unkown
HY-164826 Acetyl zingerone 99.34% Unkown
HY-155244 12R-LOX-IN-2 Inhibitor 99.85% Unkown
HY-133552 RORγt Inverse agonist 10 Antagonist 99.13% Unkown
HY-N11768 4-Methoxylonchocarpin Inhibitor 98.0% Unkown
HY-W145695 Chitoheptaose ≥98.0% Unkown
HY-128353 ROR agonist-1 Antagonist / Unkown
HY-141692A IL-17 modulator 4 sulfate Modulator / Unkown
HY-126252 A-9758 Inhibitor / Unkown
HY-130243 RORγt Inverse agonist 6 Antagonist 98.97% Unkown
HY-133128 FM26 Antagonist / Unkown
HY-142939 RORγt modulator 4 Modulator / Unkown
HY-148272 IL-17A modulator-3 Modulator 99.37% Unkown
HY-153276 Androgen receptor-IN-5 Inhibitor / Unkown
HY-155243 12R-LOX-IN-1 Inhibitor / Unkown
HY-158159 IL17A-IN-1 Inhibitor / Unkown
HY-162490 TF-S14 Inhibitor / Unkown
HY-168084 IL-17-IN-1 Inhibitor / Unkown
HY-168971 Paeoniflorin-6′-O-benzene sulfonate / Unkown
HY-169007 STAT3-IN-34 Inhibitor / Unkown
HY-169306 IL-17A inhibitor 4 Inhibitor / Unkown
HY-170611 IL-17-IN-3 Inhibitor / Unkown
HY-172806 PARP14 inhibitor 1 Inhibitor / Unkown
HY-178714 JNJ627 Inhibitor / Unkown
HY-179113 IL-17A-IN-5 Inhibitor / Unkown
HY-180608 TCR-IN-1 Inhibitor / Unkown
HY-181826 IL-17-IN-6 Inhibitor / Unkown
HY-181827 IL-17-IN-7 Inhibitor / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-183370 JAK2/STAT3-IN-2 Inhibitor / Unkown
HY-183548 XW-17 Ligand / Unkown
HY-184385 PI3K/AKT/JAK2-IN-1 Inhibitor / Unkown
HY-N13251 Verbena Extract / Unkown
HY-N8529 Eupalestin Inhibitor / Unkown
HY-P1924A IRBP(651-670) human, mouse TFA Activator / Unkown
HY-RS06695 IL17A Human Pre-designed siRNA Set A / Unkown
HY-RS06696 Il17a Mouse Pre-designed siRNA Set A / Unkown
HY-RS06697 Il17a Rat Pre-designed siRNA Set A / Unkown
HY-RS06701 IL17F Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174633 Human IL17A mRNA / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin Activator / Unkown
HY-N12481 Cephalandole B / Unkown
Inhibitory Antibodies (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990222 Anti-Mouse/Rat IL-17A Antibody (17F3) Inhibitor 99.41% Unkown
HY-P9927A Secukinumab (Anti-Human IL-17A) Antagonist 98.31% Unkown
HY-P99424 Afasevikumab Inhibitor 95% Unkown
HY-P991797 Anti-Mouse IL-17A Antibody (BZN035) Inhibitor 97.90% Unkown
HY-P991035 Turenkibart Inhibitor 99.12% Unkown
HY-P99310 Perakizumab Inhibitor 99.79% Unkown
HY-P990973 Betinukibart Inhibitor / Unkown
HY-P991116 Amdokitug 95.696% Unkown
HY-P991129 Crusekitug Ligand 97.949% Unkown
HY-P992101 Aritinercept Inhibitor 99.9% Unkown
HY-P992045 HZD37-5 Inhibitor / Unkown
HY-P990252 Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il17a NCBI NCBI:3605