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Cat. No.: HY-158159

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IL17A-IN-1

IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₅Cl₂N₇O₃
Molecular Weight:612.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

IL17A-IN-1 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.005 μM Compound: 72	Inhibition of IL171A/TNF-stimulated human HeLa cells transfected with IL17 target gene lipocalin 2 (LCN2) promotor by measuring luminescence by multimode plate reader Inhibition of IL171A/TNF-stimulated human HeLa cells transfected with IL17 target gene lipocalin 2 (LCN2) promotor by measuring luminescence by multimode plate reader	[PMID: 38574366]

In Vitro

IL17A-IN-1 inhibits Hela cells with an IC₅₀ value of 0.005 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IL17A-IN-1 (10 mg/kg; p.o.; single dose) inhibits plasma CXCL1 secretion in hIL17A-induced mouse (IL17 receptor-containing mouse) CXCL1 PD model^[1]. (Subcutaneous injection of recombinant human IL17A into mice induces plasma CXCL1 secretion).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice (hIL17A-induced mouse CXCL1 PD model)^[1].
Dosage:

10 mg/kg
Administration:

Oral administration; single dose
Result:

Inhibited 53% of CXCL1 secretion in hIL17A-induced mouse CXCL1 PD model.

Animal Model:

Male Sprague-Dawley rats; 360-460 g^[1].
Dosage:

0.3 mg/kg
Administration:

Intravenous injection; single dose
Result:

1.19 Pharmacokinetic Parameters of IL17A-IN-1 in male Sprague-Dawley rats^[1].

IV (0.3 mg/kg)

V_ss (L/kg) 5.0

t_1/2 (h) 3.6

CLp/CLp,u (L/h/kg) 1.1/6.1

Chemical Information

Molecular Weight 612.55
Formula C₃₀H₃₅Cl₂N₇O₃
SMILES

CN1CCC(N2CC3=NC([C@H](C)NC([C@@]4(NC(C5=CC(Cl)=C(Cl)N5)=O)C[C@H](OC4)C6=CC=CC=C6)=O)=NC=C3C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ramos AL, et al. Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J Med Chem. 2024 Apr 4. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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