IL17A-IN-1
IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer.
For research use only. We do not sell to patients.
- Formula: C30H35Cl2N7O3
- Molecular Weight:612.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.005 μM
Compound: 72
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Inhibition of IL171A/TNF-stimulated human HeLa cells transfected with IL17 target gene lipocalin 2 (LCN2) promotor by measuring luminescence by multimode plate reader
Inhibition of IL171A/TNF-stimulated human HeLa cells transfected with IL17 target gene lipocalin 2 (LCN2) promotor by measuring luminescence by multimode plate reader
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[PMID: 38574366] |
IL17A-IN-1 inhibits Hela cells with an IC50 value of 0.005 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (hIL17A-induced mouse CXCL1 PD model)[1].
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Dosage:10 mg/kg
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Administration:Oral administration; single dose
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Result:Inhibited 53% of CXCL1 secretion in hIL17A-induced mouse CXCL1 PD model.
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Animal Model:Male Sprague-Dawley rats; 360-460 g[1].
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Dosage:0.3 mg/kg
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Administration:Intravenous injection; single dose
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Result:
1.19 Pharmacokinetic Parameters of IL17A-IN-1 in male Sprague-Dawley rats[1].
IV (0.3 mg/kg) Vss (L/kg) 5.0 t1/2 (h) 3.6 CLp/CLp,u (L/h/kg) 1.1/6.1
Chemical Information
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Molecular Weight 612.55
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Formula C30H35Cl2N7O3
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SMILES
CN1CCC(N2CC3=NC([C@H](C)NC([C@@]4(NC(C5=CC(Cl)=C(Cl)N5)=O)C[C@H](OC4)C6=CC=CC=C6)=O)=NC=C3C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IL17A-IN-1 Related Classifications
HY-158159 Related Classifications
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