2. Immunology/Inflammation GPCR/G Protein
  3. Interleukin Related CXCR
  4. HZD37-5

HZD37-5 is a humanized monoclonal antibody specifically recognizing N78 loci of IL-17A. HZD37-5 binds to human and rhesus monkeys, blocks IL-17 induced signal transduction and the release of IL-6, IL-8, CXCL-1 and GM-GSF. HZD37-5 significantly inhibited human IL-17A induced-keratinocyte chemoattractant secretion. HZD37-5 can be used for the research of autoimmune diseases including psoriasis and psoriatic arthritis.

For research use only. We do not sell to patients.

HZD37-5

HZD37-5 Chemical Structure

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HZD37-5 Related Antibodies

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Description

HZD37-5 is a humanized monoclonal antibody specifically recognizing N78 loci of IL-17A. HZD37-5 binds to human and rhesus monkeys, blocks IL-17 induced signal transduction and the release of IL-6, IL-8, CXCL-1 and GM-GSF. HZD37-5 significantly inhibited human IL-17A induced-keratinocyte chemoattractant secretion. HZD37-5 can be used for the research of autoimmune diseases including psoriasis and psoriatic arthritis[1].

Species Reactivity

Human
IC50 & Target[1]

IL-17A

 

IL-6

 

IL-8

 

In Vitro

HZD37-5 (0.16-20 nM) exhibits very high affinity for both human and rhesus monkey IL-17A, with Kd values of 7.4 ± 0.6 pM and 5.1 pM respectively[1].
HZD37-5 (4 μg/mL, 24 h) potently inhibits human IL-17A-induced signal transduction in HEK Blue IL-17 cells[1].
HZD37-5 (0.1-10000 nM; 24 h) potently inhibits human IL-17A-induced release of the pro-inflammatory mediators IL-6, IL-8, CXCL-1, and GM-CSF in HFF-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HZD37-5 Related Antibodies

ELISA Assay[1]

Cell Line: HFF-1 cells
Concentration: 0.1-10000 nM
Incubation Time: 24 h
Result: Reduced IL-6, IL-8, CXCL-1, and GM-CSF levels.
In Vivo

HZD37-5 (0.1-10.0 mg/kg; orbital venous plexus injection; single dose) dose-dependently inhibits human IL-17A-induced Keratinocyte chemoattractan secretion in female C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6-8 weeks old)[1]
Dosage: 0.1 mg/kg; 1.0 mg/kg; 10.0 mg/kg
Administration: Orbital venous plexus injection; single dose
Result: Inhibited human IL-17A-induced KC secretion in a dose-dependent manner.
Exhibited statistically significant inhibition at P < 0.01 compared to IL-17A-only controls at 0.1, 1 and 10 mg/kg.
Gene ID

3605  [NCBI]

Accession
Target

CTLA-8/IL-17a
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[HZD37-5]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HZD37-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HZD37-5Interleukin RelatedCXCRILCXC chemokine receptorsC-X-C motif chemokine receptorsIL-17AIL-6N78 locusG-CSFIL-8CXCL-1rhesus monkey IL-17AHEK Blue IL-17 cellsInterleukin-17Asignal transductionInhibitorinhibitorinhibit

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