1. Immunology/Inflammation
  2. Interleukin Related
  3. Ustekinumab

Ustekinumab (Synonyms: Anti-Human IL-12/IL-23, Human Antibody)

Cat. No.: HY-P9909 Purity: 98.42%
Handling Instructions

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

For research use only. We do not sell to patients.

Ustekinumab Chemical Structure

Ustekinumab Chemical Structure

CAS No. : 815610-63-0

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1 mg USD 828 In-stock
Estimated Time of Arrival: December 31
5 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

IC50 & Target

IL-12, IL-23[1]

In Vitro

Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells[1]. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (KD) is calculated relative to Ustekinumab (Ustekinumab=1.0)[2].

Clinical Trial
Molecular Weight

145625.97

CAS No.

815610-63-0

SMILES

[Ustekinumab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[2]

HUVECs are grown on calibrated glass coverslips to a confluency of 80%. Subsequently, cells are incubated with 200 µg/mL Ustekinumab AlexaFluor488 and Briakinumab AlexaFluor594 for 20 min at 37°C, pH 7.3, washed three times, and chased in fresh medium for an additional 20 min before fixation. Antibodies are directly labeled. FcRn binding is quality controlled by SPR analysis. Cells are then counterstained with anti-FcRn monoclonal antibody DVN22, followed by anti-mouse secondary antibodies conjugated to AlexaFluor647. Imaging is performed on a Leica SP8 confocal microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 98.42%

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