IL12B - interleukin 12B Gene

Also Known as CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3593

About IL12B

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:159,314,780-159,330,487 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

IL12B Products (1)

mRNA	Protein	Name
NM_002187.3	NP_002178.2	interleukin-12 subunit beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to cytokine activity	IDA IDA: Inferred from direct assay	1674604	GOA
enables cytokine activity	IDA IDA: Inferred from direct assay	7584494	GOA
contributes to growth factor activity	IDA IDA: Inferred from direct assay	1674604	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	7527811	GOA
enables interleukin-12 alpha subunit binding	IPI IPI: Inferred from physical interaction	11023671	GOA
contributes to interleukin-23 receptor binding	IDA IDA: Inferred from direct assay	11114383	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7527811	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	1674604	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper cell differentiation	IDA IDA: Inferred from direct assay	1673147	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	7903063	GOA
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	12023369	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	15114670	GOA
involved in interleukin-12-mediated signaling pathway	IDA IDA: Inferred from direct assay	7584494	GOA
involved in natural killer cell activation	IDA IDA: Inferred from direct assay	1673147	GOA
acts upstream of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	30106099	GOA
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	16751425	GOA
involved in negative regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	16482511	GOA
acts upstream of or within negative regulation of protein secretion	IGI IGI: Inferred from genetic interaction	30106099	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	16942485	GOA
acts upstream of negative regulation of vascular endothelial growth factor signaling pathway	IGI IGI: Inferred from genetic interaction	30106099	GOA
involved in positive regulation of NK T cell activation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of NK T cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12023369	GOA
involved in positive regulation of T-helper 1 type immune response	IDA IDA: Inferred from direct assay	15114670	GOA
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	1674604	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	7903063	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	12421946	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	20027291	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	15265908	GOA
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	20027291	GOA
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	16482511	GOA
involved in positive regulation of lymphocyte proliferation	IDA IDA: Inferred from direct assay	1674604	GOA
involved in positive regulation of mononuclear cell proliferation	IMP IMP: Inferred from mutant phenotype	11023671	GOA
involved in positive regulation of natural killer cell activation	IDA IDA: Inferred from direct assay	1674604	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	7903063	GOA
involved in positive regulation of natural killer cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	17888176	GOA
involved in positive regulation of smooth muscle cell apoptotic process	IDA IDA: Inferred from direct assay	16942485	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16751425	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	1674604	GOA
involved in response to UV-B	IDA IDA: Inferred from direct assay	8992506	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	7584494	GOA
part of interleukin-12 complex	IDA IDA: Inferred from direct assay	1674604	GOA
part of interleukin-23 complex	IDA IDA: Inferred from direct assay	11114383	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL12B Protein Structure

IL12p40_C

0
100
200
300
328 a.a.

Protein Preferred Names	Protein Names
interleukin-12 subunit beta	CLMF p40 IL-12 subunit p40 IL12, subunit p40 NK cell stimulatory factor chain 2 cytotoxic lymphocyte maturation factor 40 kDa subunit interleukin 12, p40 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) interleukin-12 beta chain natural killer cell stimulatory factor, 40 kD subunit

IL12B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL12B	P29460	IL12B	Homo sapiens	P29460	Chromatography	7527811
Intra	IL12B	P29460	IL23A	Homo sapiens	Q9NPF7	BRET	29997244
Intra	IL12B	P29460	IL23A	Homo sapiens	Q9NPF7	Lumier	29997244
Intra	IL12B	P29460	IL12B	Homo sapiens	P29460	Comig Non-Denat Gel	7527811
Cross	IL12B	P29460	Il23a	Mus musculus	Q9EQ14	Anti Tag CoIP	11114383
Intra	IL12B	P29460	IL23A	Homo sapiens	Q9NPF7	Anti Bait CoIP	11114383
Cross	IL12B	P29460	Il23a	Mus musculus	Q9EQ14	Anti Bait CoIP	11114383
Intra	IL12B	P29460	IL12A	Homo sapiens	P29459	X-Ray Diffraction	10899108

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL12B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7032	IL-12 Protein, Human (HEK293)	P29459 (R23-S219)&P29460 (I23-S328)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70617	IL-12 beta Protein, Human (HEK293)	P29460 (I23-S328)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70736	IL-23 Protein, Human (HEK293, C-His)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P7032G	GMP IL-12 Protein, Human (HEK293)	P29459 (R23-S219)&P29460 (I23-S328)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73160	IL-12 beta Protein, Human (HEK293, Fc)	P29460/NP_002178.2 (I23-S328)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P73193	IL-23 Protein, Human (HEK293, His)	Q9NPF7/NP_057668.1 (R20-P189)&P29460/NP_002178.2 (I23-S328)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73898	IL-12 Protein, Human (HEK293, His)	P29459 (R23-S219)&P29460 (I23-S328)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74816	IL-23 Protein, Human (Biotinylated, HEK293, His)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77702	IL-12 Protein, Human (Biotinylated, HEK293, His-Avi)	P29459 (R23-S219)&P29460 (I23-S328)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700100AF	Animal-Free IL-12 beta Protein, Human (His)	P29460 (I23-S328)	≥ 95%, as determined by reducing SDS-PAGE.

IL12B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810795	IL-12 beta Antibody (YA10038)	WB, ICC/IF, FC	Human, Mouse, Rat
HY-P83008	IL-12 beta Antibody (YA2753)	WB	Human

Related Diseases

Diseases	Alias
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Psoriasis
Psoriasis 11	PSORS11 Psoriasis 11, Susceptibility To Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Pv
Immunodeficiency 29	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency IMD29 Il12b Deficiency Immunodeficiency 29, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency Msmd Due To Complete Il12b Deficiency Msmd Due To Complete Interleukin 12b Deficiency Immunodeficiency, Type 29, Mycobacteriosis
Typhoid Fever	Typhoid Enteric Fever Typhoidal Salmonellosis Ileotyphus Infection By Salmonella Typhi Typhoid Any Site Typhoid Fever Any Site Typhoid Infection Typhoid Infection Any Site Typhoid Fever Confirmed Enteric Fever Nos
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Chronic Adenitis Acute Adenitis Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Paratyphoid Fever	Paratyphoid B Fever Paratyphoid C Fever Paratyphoid Fever A Paratyphoid Fever B Paratyphoid Fever C Paratyphoid Paratyphoid A Paratyphoid A Fever Paratyphoid B Paratyphoid C Infection Due To Salmonella Paratyphi
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Cysticercosis	Neurocysticercosis Submacular Cysticercosis Intestinal Taenia Solium Infection Pork Tapeworm Infection Tapeworm Infection: Intestinal Taenia Solum Tapeworm Infection: Pork Tenia Solium Infectious Disease Taeniasis Tenia Solium Infection Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Inflammatory Bowel Disease 3	IBD3
Pulmonary Tuberculosis	Tuberculosis, Pulmonary PTB Tuberculosis Pulmonary
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Inflammatory Bowel Disease 9	IBD9
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Idiopathic Aortitis Young Female Arteritis Takayasu'S Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06680	IL12B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06681	Il12b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06682	Il12b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174617	Human IL23A mRNA		/	Unkown
HY-174641	Human IL12B mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL12B	VGNC	VGNC:73706
Felis catus	IL12B	VGNC	VGNC:67756
Canis familiaris	IL12B	VGNC	VGNC:41933
Rattus norvegicus	IL12B	RGD	RGD:628704
Mus musculus	IL12B	MGD	MGI:96540
Bos taurus	IL12B	VGNC	VGNC:30111
Others	IL12B	NCBI