1. GPCR/G Protein
  2. LPL Receptor
  3. IMMH001

IMMH001 

Cat. No.: HY-147660
Handling Instructions

IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research.

For research use only. We do not sell to patients.

IMMH001 Chemical Structure

IMMH001 Chemical Structure

CAS No. : 1418093-75-0

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Description

IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research[1][2].

IC50 & Target

S1PR1

 

In Vivo

IMMH001 is converted to the active form, its monophosphate ester (S)-IMMH001-P, by sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2) in vivo[1].
IMMH001 suppresses both Th1 cell (IL-1β, IL-18, and IP10) and Th2 cell (IL-5)-mediated disease reactions in damaged joints[2].
IMMH001 (0.3-2.4 mg/kg, Orally; twice a week, for 28 days, AA rats; for 30 days, CIA rats) relieves the damage of AA (adjuvant-induced arthritis) and CIA (collagen-induced arthritis) rats’ joints[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

380.48

Formula

C23H28N2O3

CAS No.
SMILES

CCCC1=NC(C2=CC=C(C=C2)C3=CC=C(C=C3)CCC(CO)(CO)N)=CO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IMMH001
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