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  5. IL-5 Protein, Cynomolgus (sf9, His)

IL-5 Protein, Cynomolgus (sf9, His)

Cat. No.: HY-P73878
Handling Instructions

IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of IL-5 Protein, Cynomolgus (sf9, His) is 134 a.a., with molecular weight of ~14.6 kDa.

For research use only. We do not sell to patients.

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Description

IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of IL-5 Protein, Cynomolgus (sf9, His) is 134 a.a., with molecular weight of ~14.6 kDa.

Background

IL-5 Protein is a homodimeric cytokine primarily produced by T-lymphocytes and NK cells, playing a crucial role in eosinophil survival, differentiation, and chemotaxis. It also acts on B-cells, stimulating immunoglobulin production, growth, and differentiation. IL-5 Protein exerts its effects through a receptor composed of IL5RA and CSF2RB subunits, leading to the activation of various kinases such as LYN, SYK, and JAK2. This activation propagates signals through the RAS-MAPK and JAK-STAT5 pathways. IL-5 Protein exists as a disulfide-linked homodimer.

Species

Cynomolgus

Source

Sf9 insect cells

Tag

C-His

Accession

A0A2K5U1E7 (M1-S134)

Gene ID

/

Molecular Construction
N-term
IL-5 (M1-S134)
Accession # A0A2K5U1E7
His
C-term
Synonyms
Interleukin-5; IL-5; EDF; Eo-CSF; TRF
Molecular Weight

Approximately 14.6 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

IL-5 Protein, Cynomolgus (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
IL-5 Protein, Cynomolgus (sf9, His)
Cat. No.:
HY-P73878
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