2. Apoptosis
  3. Apoptosis
  4. Lirentelimab

Lirentelimab  (Synonyms: AK002; Anti-Siglec-8 Reference Antibody (lirentelimab))

Cat. No.: HY-P99371 Purity: 99.91%
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Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis.

For research use only. We do not sell to patients.

Lirentelimab Chemical Structure

Lirentelimab Chemical Structure

CAS No. : 2283348-97-8

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Description

Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis[1].

In Vitro

Monovalent Lirentelimab fragment antigen-binding (fab) binds to recombinant SIGLEC8 extracellular domain (ECD) is determined to be 464 pM[1].
Lirentelimab shows high affinity to SIGLEC8 in vitro, to SIGLEC8 expressed on eosinophils, and to NK cells via its Fc region in human blood[1].
Lirentelimab (1 µg/mL) selectively binds to eosinophils in human peripheral blood, and eosinophils and mast cells from human lung tissue[1].
Lirentelimab (0.0001-100 μg/mL; 30 min) induces apoptosis of IL-5-activated eosinophils[1].
Lirentelimab (30 min) shows potent antibody-dependent cell-mediated cytotoxicity (ADCC) Activity on human eosinophils with an EC50 value of 1.9 ng/mL to eosinophils in peripheral blood leukocytes (PBL) preparations from healthy donors[1].
Lirentelimab reduces eosinophil numbers in ex vivo human tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lirentelimab Related Antibodies

Apoptosis Analysis[1]

Cell Line: Eosinophils
Concentration: 10 μg/mL-1 pg/mL
Incubation Time: 30 min
Result: Dose-dependently induced apoptosis of IL-5-activated (50 ng/mL) eosinophils.
In Vivo

Lirentelimab (100 μg; i.v. once) significantly inhibits IgE-mediated mast cell activation in a mice model of systemic anaphylaxis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized mice (NSG-SGM3) engrafts with human thymus, liver, and HSC[1]
Dosage: 100 μg
Administration: Intravenous injection; 100 μg, once
Result: Completely prevented passive systemic anaphylaxis (PSA) as shown by a lack of change in rectal temperature and symptom scores in mice.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Lirentelimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.91%

COA (231 KB)

Handling Instructions (2659 KB)
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Lirentelimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lirentelimab2283348-97-8AK002 Anti-Siglec-8 Reference Antibody (lirentelimab)AK 002AK-002Apoptosismonoclonal antibodyapoptosiseosinophilmast cellduodenitiseosinophilic gastritishuman bloodADCCInhibitorinhibitorinhibit

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