SIGLEC8 - sialic acid binding Ig like lectin 8 Gene

Also Known as SAF2; SIGLEC-8; SIGLEC8L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27181

About SIGLEC8

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,450,997-51,458,454 (from NCBI)

This gene has 4 transcripts (splice variants), 91 orthologues and 16 paralogues. Broad expression in lymph node (RPKM 2.6), spleen (RPKM 2.6) and 14 other tissues.

Summary

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]

SIGLEC8 Products (2)

mRNA	Protein	Name
NM_001363548.1	NP_001350477.1	sialic acid-binding Ig-like lectin 8 isoform 2 precursor
NM_014442.3	NP_055257.2	sialic acid-binding Ig-like lectin 8 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC8 Protein Structure

V-set

ig

Ig_2

0
100
200
300
400
499 a.a.

Protein Preferred Names	Protein Names
sialic acid-binding Ig-like lectin 8	CDw329

SIGLEC8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SIGLEC8	Q9NYZ4	TFF1	Homo sapiens	P04155	Protein Array	21982860
Intra	SIGLEC8	Q9NYZ4	TFF1	Homo sapiens	P04155	SPR	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGLEC8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71312	Siglec-8 Protein, Human (HEK293, Fc)	Q9NYZ4-1 (M17-A363)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71313	Siglec-8 Protein, Human (HEK293, His)	Q9P0M4/NP_037410.1 (M17-A363)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78204	Siglec-8 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9P0M4 (M17-A363)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78513	Siglec-8 Protein, Human (HEK293, His-Avi)	NP_037410.1 (M17-A363)	≥ 95%, as determined by Bis-Tris PAGE.

SIGLEC8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84840	SIGLEC8 Antibody (YA4537)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84840A	SIGLEC8 Antibody (YA4537)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Eosinophilic Gastritis	Eosinophilic Enteropathy
Chronic Inducible Urticaria
Indolent Systemic Mastocytosis	Ism
Duodenitis	Hemorrhagic Duodenitis Acute Enteritis Of The Mouse Intestinal Tract Nonspecific Duodenitis Inflammation Of Duodenum Dodecadactylitis Duodenal Inflammation Peptic Duodenitis
Eosinophilic Gastroenteritis	Eosinophilic Enteritis Ege Eosinophilic Gastroenterocolitis Eosinophilic Esophagitis Eosinophilic Gastritis Eosinophilic Gastroenteropathy Gastroenteritis, Eosinophilic Eosinophilic Enteropathy
Congenital Disorder Of Glycosylation, Type Iic	CDG2C Congenital Disorder Of Glycosylation Type Iic Leukocyte Adhesion Deficiency Type Ii Cdg Iic Cdgiic Rambam-Hasharon Syndrome Leukocyte Adhesion Deficiency, Type Ii Lad2 Leukocyte Adhesion Deficiency 2 Cdg-Iic Congenital Disorder Of Glycosylation, Type 2c Rhs Cdg Syndrome Type Iic Lad-Ii Rambam Hasharon Syndrome Congenital Disorder Of Glycosylation 2c Glycosylation, Congenital Disorder Of, Type Iic
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Chronic Frontal Sinusitis
Dermatographia	Dermatographic Urticaria Dermographism Symptomatic Dermographism Urticaria Factitia Factitious Urticaria Dermatographism
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99371	Lirentelimab	Inducer	99.91%	Phase 3
HY-P991071	AK-001	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12906	SIGLEC8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25064	Siglec8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SIGLEC8	RGD	RGD:1563073
Others	SIGLEC8	NCBI