2. Neuronal Signaling Anti-infection
  3. Monoamine Oxidase Influenza Virus
  4. Eckol

Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects.

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Eckol Chemical Structure

Eckol Chemical Structure

CAS No. : 88798-74-7

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Eckol Related Antibodies

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Description

Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects[1][2][3][4].

IC50 & Target[1][4]

hMAO-A

7.20 μM (IC50)

hMAO-B

83.44 μM (IC50)

H1N1

89.5 μM (IC50)

In Vitro

Pretreatment with Eckol (25-100 μg/mL; 2 h) significantly reduces β-hexosaminidase release in IgE/BSA-stimulated BMCMC in a dose-dependent manner[3].
Eckol (25-100 μg/mL; 1 h) inhibits the production of Th2-type cytokines, such as IL-4, IL-5, and IL-13 as well as proinflammatory cytokines, such as IL-6[3].
Eckol (25-100 μg/mL) attenuates cytokine mRNA levels such as IL-1β, IL-4, IL-5, IL-6, IL-13, IFN-γ, and TNF-α in IgE/BSA-stimulated BMCMC[3].
Eckol (25-100 μg/mL; 1 h) inhibits NF-κB activation in IgE/BSA-stimulated BMCMC[3].
Eckol showes a moderate IC50 value (89.5 µM) against the influenza A/Bervig-Mission/1/18 (H1N1) virus[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eckol Related Antibodies

Western Blot Analysis[3]

Cell Line: Bone marrow-derived cultured mast cells (BMCMC)
Concentration: 25, 50 and 100 μg/mL
Incubation Time: 1 h
Result: Inhibited the degradation of IκB-α within the cytosol and the translocation of the NF-κB/p65 subunit into the nucleus that were induced by IgE/BSA.
In Vivo

Foliar application of Eckol (1 μM) significantly enhanced shoot and root length, shoot and root fresh and dry weight, leaf area and leaf number[2].
Eckol (50 or 100 μg/mouse; intradermal; once) reduces allergic inflammatory responses in the passive cutaneous anaphylaxis (PCA)-induced mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (8 weeks old), IgE/BSA-induced passive cutaneous anaphylaxis (PCA) model[3]
Dosage: 50 or 100 μg/mouse
Administration: Intradermal injection, applied on mice ear 2 h prior to anaphylaxis induction
Result: Reduced allergic inflammatory responses.
Molecular Weight

372.28

Formula

C18H12O9
CAS No.
SMILES

OC1=C2C(OC3=C(O)C=C(O)C=C3O2)=C(OC4=CC(O)=CC(O)=C4)C(O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eckol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eckol88798-74-7Monoamine OxidaseInfluenza VirusMAOβ-hexosaminidaseTh2-type cytokinesIL-1βIL-4IL-6IL-5IL-13TNF-αIFN-γBMCMCBone marrow-derived cultured mast cellsH1N1Inhibitorinhibitorinhibit

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