CDK4/6-IN-21
CDK4/6-IN-21 (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2102887-41-0
- Formula: C27H30F2N8
- Molecular Weight:504.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
CDK4 3.88 nM (IC50) |
CDK6 3.31 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1745 nM
Compound: 3d
|
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
|
[PMID: 31200237] |
| COLO 205 | IC50 |
248 nM
Compound: 3d
|
Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
|
[PMID: 31200237] |
| MCF7 | IC50 |
20.1 nM
Compound: 3d
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
|
[PMID: 31200237] |
| T47D | IC50 |
19.4 nM
Compound: 3d
|
Antiproliferative activity against human T47D cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human T47D cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
|
[PMID: 31200237] |
| ZR-75-1 | IC50 |
46.4 nM
Compound: 3d
|
Antiproliferative activity against human ZR-75-1 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human ZR-75-1 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
|
[PMID: 31200237] |
Chemical Information
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CAS No. 2102887-41-0
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Molecular Weight 504.58
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Formula C27H30F2N8
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SMILES
FC1=C(C2=CC3=C(N=C(C)N3C4CC4)C(F)=C2)N=C(NC5=CC=C(CN(CCN(C)C)CC6)C6=N5)N=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)