CDK4/6-IN-7
CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC50s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2649120-20-5
- Formula: C18H18ClN5O3
- Molecular Weight:387.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK4 1.58 nM (IC50) |
CDK6 4.09 nM (IC50) |
CDK4/6-IN-7 (compound 7c) (0.1-656.1 µM; 48 h) inhibits the viability of MCF-7 cells, with an IC50 of 0.92 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, 656.1 µM
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Incubation Time:48 hours
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Result:Inhibited MCF-7 cells growth, with an IC50 of 0.92 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nude mice (5 weeks) bearing MCF-7 tumor[1]
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Dosage:50 mg/kg
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Administration:Oral gavage once daily for 7 days
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Result:Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.
Chemical Information
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CAS No. 2649120-20-5
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Molecular Weight 387.82
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Formula C18H18ClN5O3
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SMILES
O=C(C1=CC=CC=C1Cl)NNC(N2CCC[C@@H]2C(NC3=CC=CN=C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK4/6-IN-7 Related Classifications
HY-143257 Related Classifications
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