1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK4/6-IN-7

CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC50s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

CDK4/6-IN-7 Chemical Structure

CDK4/6-IN-7 Chemical Structure

CAS No. : 2649120-20-5

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Description

CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC50s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer[1].

IC50 & Target[1]

CDK4

1.58 nM (IC50)

CDK6

4.09 nM (IC50)

In Vitro

CDK4/6-IN-7 (compound 7c) (0.1-656.1 µM; 48 h) inhibits the viability of MCF-7 cells, with an IC50 of 0.92 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells
Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, 656.1 µM
Incubation Time: 48 hours
Result: Inhibited MCF-7 cells growth, with an IC50 of 0.92 μM.
In Vivo

CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (5 weeks) bearing MCF-7 tumor[1]
Dosage: 50 mg/kg
Administration: Oral gavage once daily for 7 days
Result: Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.
Molecular Weight

387.82

Formula

C18H18ClN5O3

CAS No.
SMILES

O=C(C1=CC=CC=C1Cl)NNC(N2CCC[C@@H]2C(NC3=CC=CN=C3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CDK4/6-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CDK4/6-IN-7
Cat. No.:
HY-143257
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