FLT3-IN-17
Based on 1 Customer Validation
FLT3-IN-17 inhibits CYPs and FLT3 mutants activity (IC50s: <0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC50 value of 12 nM. FLT3 ligand-2 can be used in the research of cancers.
For research use only. We do not sell to patients.
- Purity: 99.11%
- CAS No.: 2758999-62-9
- Formula: C23H24N6O2S2
- Molecular Weight:480.61
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 12 nM (FAK), <0.5 nM (D835Y)[2].
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A375P | GI50 |
0.49 μM
Compound: 25
|
Antiproliferative activity against human A375P cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human A375P cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34324343] |
| BaF3 | GI50 |
1.6 nM
Compound: 25
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Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 D835Y mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 D835Y mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34324343] |
| BaF3 | GI50 |
103 nM
Compound: 25
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Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD F691L mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD F691L mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34324343] |
| BaF3 | GI50 |
11 nM
Compound: 25
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Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD D835Y mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD D835Y mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34324343] |
| BaF3 | GI50 |
183.2 nM
Compound: 25
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Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD F691I mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD F691I mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
|
[PMID: 34324343] |
| BaF3 | GI50 |
550 nM
Compound: 25
|
Antiproliferative activity against mouse Ba/F3 cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse Ba/F3 cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
|
[PMID: 34324343] |
| BaF3 | GI50 |
7.4 nM
Compound: 25
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Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse Ba/F3 cells harbouring FLT3 ITD mutant assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
|
[PMID: 34324343] |
| HCT-116 | GI50 |
0.25 μM
Compound: 25
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Antiproliferative activity against human HCT-116 cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HCT-116 cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34324343] |
| MDA-MB-231 | GI50 |
0.46 μM
Compound: 25
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Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 72 hrs by CellTiter-Glo assay
|
[PMID: 34324343] |
FLT3-IN-17 (compound 25, 72 h) inhibits cell growth in HCT-116, MDA-MB-231, A375 cells[1].
FLT3-IN-17 (10 μM) inhibits cytochrome P450s (CYPs) with inhibition rates >55%[1].
FLT3-IN-17 inhibits FLT3 mutants activity (IC50s: <0.5 nM for D835Y, 1.6-183 nM for Ba/F3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, MDA-MB-231, A375 cells
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Concentration:0-1 μM approximately
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Incubation Time:72 h
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Result:Inhibited cell growth with IC50 values of 0.25, 0.46, 0.49 μM respectively.
Chemical Information
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CAS No. 2758999-62-9
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Appearance Solid
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Molecular Weight 480.61
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Formula C23H24N6O2S2
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Color Light yellow to yellow
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SMILES
O=S(NC1=CC=CC(C2=CSC3=C2N=C(NC4=CC=C(N5CCNCC5)C=C4)N=C3)=C1)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 7.5 mg/mL (15.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0807 mL | 10.4034 mL | 20.8069 mL | 52.0172 mL |
| 5 mM | 0.4161 mL | 2.0807 mL | 4.1614 mL | 10.4034 mL | |
| 10 mM | 0.2081 mL | 1.0403 mL | 2.0807 mL | 5.2017 mL | |
| 15 mM | 0.1387 mL | 0.6936 mL | 1.3871 mL | 3.4678 mL |
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