FLT3-IN-17 

FLT3-IN-17 inhibits CYPs and FLT3 mutants activity (IC₅₀s: <0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC₅₀ value of 12 nM. FLT3 ligand-2 can be used in the research of cancers^[1].

IC50: 12 nM (FAK), <0.5 nM (D835Y)^[2].

FLT3-IN-17 (compound 25, 72 h) inhibits cell growth in HCT-116, MDA-MB-231, A375 cells^[1].
FLT3-IN-17 (10 μM) inhibits cytochrome P450s (CYPs) with inhibition rates >55%^[1].
FLT3-IN-17 inhibits FLT3 mutants activity (IC₅₀s: <0.5 nM for D835Y, 1.6-183 nM for Ba/F3)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

480.61

C₂₃H₂₄N₆O₂S₂

2758999-62-9

Solid

Light yellow to yellow

O=S(NC1=CC=CC(C2=CSC3=C2N=C(NC4=CC=C(N5CCNCC5)C=C4)N=C3)=C1)(C)=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Hanna Cho, et al. Identification of Thieno[3,2- d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3. J Med Chem. 2021 Aug 26;64(16):11934-11957.  [Content Brief]