1. Cell Cycle/DNA Damage
  2. CDK
  3. Abemaciclib metabolite M2

Abemaciclib metabolite M2 (Synonyms: LSN2839567)

Cat. No.: HY-128669 Purity: 99.82%
Handling Instructions

Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity.

For research use only. We do not sell to patients.

Abemaciclib metabolite M2 Chemical Structure

Abemaciclib metabolite M2 Chemical Structure

CAS No. : 1231930-57-6

Size Price Stock Quantity
1 mg USD 320 In-stock
Estimated Time of Arrival: December 31
5 mg USD 960 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1].

IC50 & Target[1]

CDK4

1-3 nM (IC50)

CDK6

1-3 nM (IC50)

Molecular Weight

478.54

Formula

C₂₅H₂₈F₂N₈

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (4.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0897 mL 10.4484 mL 20.8969 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.82%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Abemaciclib metabolite M2
Cat. No.:
HY-128669
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