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Cat. No.: HY-128669R

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Abemaciclib metabolite M2 (Standard)

(Synonyms: LSN2839567 (Standard))

Abemaciclib metabolite M2 (Standard) is the analytical standard of Abemaciclib metabolite M2. This product is intended for research and analytical applications. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 1231930-57-6
Formula: C₂₅H₂₈F₂N₈
Molecular Weight:478.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Abemaciclib metabolite M2 (Standard) Chemical Structure

CAS No.: 1231930-57-6

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1231930-57-6
Molecular Weight 478.54
Formula C₂₅H₂₈F₂N₈
SMILES

CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C
Synonyms

LSN2839567 (Standard)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).

[2]. CHMP. Assessment report Verzenios. 26 July 2018 EMA/551438/2018.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Abemaciclib metabolite M2 (Standard)

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Abemaciclib metabolite M2 (Standard)

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Abemaciclib metabolite M2 (Standard) Related Classifications

HY-128669R Related Classifications