Carbonic anhydrase inhibitor 33
Carbonic anhydrase inhibitor 33 (11D) is a dual inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with Ki values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC.
For research use only. We do not sell to patients.
- Formula: C19H15FN6O2S
- Molecular Weight:410.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA IX 19.7 nM (Ki) |
hCA XII 26.1 nM (Ki) |
hCA II 76.1 nM (Ki) |
hCA I 663 nM (Ki) |
CDK6 0.069 μM (IC50) |
Carbonic anhydrase inhibitor 33 (11D) exhibits IC50 values of 2.39 μM and 7.92 μM in A549 and NCI-H1734 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 410.42
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Formula C19H15FN6O2S
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SMILES
O=S(C1=CC=C(/N=N/C2=C3N=CC=C(C4=CC=C(F)C=C4)N3N=C2C)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbonic anhydrase inhibitor 33 Related Classifications
HY-172899 Related Classifications
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