2. PROTAC Cell Cycle/DNA Damage Apoptosis
  3. PROTACs CDK Apoptosis
  4. PROTAC CDK6 Degrader 1

PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. PROTAC CDK6 Degrader 1 exhibits selectivity over CDK4 (DC50 > 10 μM). PROTAC CDK6 Degrader 1 induces G0/G1 cell-cycle arrest and apoptosis through inhibition of CDK6 downstream signaling. PROTAC CDK6 Degrader 1 reduces tumor burden and CDK6 levels in a MOLM-14 xenograft mouse model. PROTAC CDK6 Degrader 1 can be used for CDK6-driven cancers research, such as acute myeloid leukemia (AML).
(Pink: CDK and CDK6 ligand (HY-180278); Blue: Ligands for E3 Ligase and KLHDC2 ligand (HY-180280); Black: linker).

For research use only. We do not sell to patients.

PROTAC CDK6 Degrader 1

PROTAC CDK6 Degrader 1 Chemical Structure

Size Price Stock Quantity
5 mg Get quote 12 - 14 Weeks 11 - 13 Weeks 13 - 15 Weeks 12 - 14 weeks
10 mg Get quote 12 - 14 Weeks 11 - 13 Weeks 13 - 15 Weeks 12 - 14 weeks
25 mg Get quote 12 - 14 Weeks 11 - 13 Weeks 13 - 15 Weeks 12 - 14 weeks
50 mg Get quote 12 - 14 Weeks 11 - 13 Weeks 13 - 15 Weeks 12 - 14 weeks
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

PROTAC CDK6 Degrader 1 Related Antibodies

Top Publications Citing Use of Products

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Description

PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. PROTAC CDK6 Degrader 1 exhibits selectivity over CDK4 (DC50 > 10 μM). PROTAC CDK6 Degrader 1 induces G0/G1 cell-cycle arrest and apoptosis through inhibition of CDK6 downstream signaling. PROTAC CDK6 Degrader 1 reduces tumor burden and CDK6 levels in a MOLM-14 xenograft mouse model. PROTAC CDK6 Degrader 1 can be used for CDK6-driven cancers research, such as acute myeloid leukemia (AML)[1]. (Pink: CDK and CDK6 ligand (HY-180278); Blue: Ligands for E3 Ligase and KLHDC2 ligand (HY-180280); Black: linker).

IC50 & Target[1]

CDK6

0.037 μM (DC50)

Molecular Weight

1268.55

Formula

C70H89N15O8
SMILES

O=C([C@@H]1CN(CCC1)C2=C3C=CC=CC3=CN=C2)N(CC4=CN(N=C4)CC(OC)=O)CCNC([C@H]5CC[C@H](C(N6CCC7(CC(C7)N8CCC(CC8)C(N9CCN(C%10=CN=C(NC%11=NC=C%12C(N(C(C(C(C)=O)=C%12C)=O)C%13CCCC%13)=N%11)C=C%10)CC9)=O)CC6)=O)CC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC CDK6 Degrader 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC CDK6 Degrader 1PROTACsCDKApoptosisCyclin dependent kinaseMOLM-14 cellsxenograft mouse modelCDK6-driven cancersacute myeloid leukemiaInhibitorinhibitorinhibit

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