PROTAC CDK6 Degrader 1
Based on 1 Customer Validation
PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. PROTAC CDK6 Degrader 1 exhibits selectivity over CDK4 (DC50 > 10 μM). PROTAC CDK6 Degrader 1 induces G0/G1 cell-cycle arrest and apoptosis through inhibition of CDK6 downstream signaling. PROTAC CDK6 Degrader 1 reduces tumor burden and CDK6 levels in a MOLM-14 xenograft mouse model. PROTAC CDK6 Degrader 1 can be used for CDK6-driven cancers research, such as acute myeloid leukemia (AML).
(Pink: CDK6 ligand (HY-180278); Blue: KLHDC2 ligand (HY-180280); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.89%
- 分子式: C70H89N15O8
- 分子量:1268.55
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保管条件:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
CDK6 0.037 μM (DC50) |
化学情報
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性状 Solid
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分子量 1268.55
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分子式 C70H89N15O8
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Color Light yellow to yellow
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SMILES
O=C([C@@H]1CN(CCC1)C2=C3C=CC=CC3=CN=C2)N(CC4=CN(N=C4)CC(OC)=O)CCNC([C@H]5CC[C@H](C(N6CCC7(CC(C7)N8CCC(CC8)C(N9CCN(C%10=CN=C(NC%11=NC=C%12C(N(C(C(C(C)=O)=C%12C)=O)C%13CCCC%13)=N%11)C=C%10)CC9)=O)CC6)=O)CC5)=O
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輸送条件
Shipping with dry ice.
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保管条件
-80°C, protect from light
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (39.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.7883 mL | 3.9415 mL | 7.8830 mL | 19.7075 mL |
| 5 mM | 0.1577 mL | 0.7883 mL | 1.5766 mL | 3.9415 mL | |
| 10 mM | 0.0788 mL | 0.3942 mL | 0.7883 mL | 1.9708 mL | |
| 15 mM | 0.0526 mL | 0.2628 mL | 0.5255 mL | 1.3138 mL | |
| 20 mM | 0.0394 mL | 0.1971 mL | 0.3942 mL | 0.9854 mL | |
| 25 mM | 0.0315 mL | 0.1577 mL | 0.3153 mL | 0.7883 mL | |
| 30 mM | 0.0263 mL | 0.1314 mL | 0.2628 mL | 0.6569 mL |
PROTAC CDK6 Degrader 1 関連分類
HY-180277 関連分類
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