PROTAC CDK6 Degrader 1
Based on 1 Customer Validation
PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. PROTAC CDK6 Degrader 1 exhibits selectivity over CDK4 (DC50 > 10 μM). PROTAC CDK6 Degrader 1 induces G0/G1 cell-cycle arrest and apoptosis through inhibition of CDK6 downstream signaling. PROTAC CDK6 Degrader 1 reduces tumor burden and CDK6 levels in a MOLM-14 xenograft mouse model. PROTAC CDK6 Degrader 1 can be used for CDK6-driven cancers research, such as acute myeloid leukemia (AML).
(Pink: CDK6 ligand (HY-180278); Blue: KLHDC2 ligand (HY-180280); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.89%
- Formula: C70H89N15O8
- Molecular Weight:1268.55
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Storage:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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CDK6 0.037 μM (DC50) |
Chemical Information
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Appearance Solid
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Molecular Weight 1268.55
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Formula C70H89N15O8
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Color Light yellow to yellow
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SMILES
O=C([C@@H]1CN(CCC1)C2=C3C=CC=CC3=CN=C2)N(CC4=CN(N=C4)CC(OC)=O)CCNC([C@H]5CC[C@H](C(N6CCC7(CC(C7)N8CCC(CC8)C(N9CCN(C%10=CN=C(NC%11=NC=C%12C(N(C(C(C(C)=O)=C%12C)=O)C%13CCCC%13)=N%11)C=C%10)CC9)=O)CC6)=O)CC5)=O
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Solvent & Solubility
DMSO : 50 mg/mL (39.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.7883 mL | 3.9415 mL | 7.8830 mL | 19.7075 mL |
| 5 mM | 0.1577 mL | 0.7883 mL | 1.5766 mL | 3.9415 mL | |
| 10 mM | 0.0788 mL | 0.3942 mL | 0.7883 mL | 1.9708 mL | |
| 15 mM | 0.0526 mL | 0.2628 mL | 0.5255 mL | 1.3138 mL | |
| 20 mM | 0.0394 mL | 0.1971 mL | 0.3942 mL | 0.9854 mL | |
| 25 mM | 0.0315 mL | 0.1577 mL | 0.3153 mL | 0.7883 mL | |
| 30 mM | 0.0263 mL | 0.1314 mL | 0.2628 mL | 0.6569 mL |
PROTAC CDK6 Degrader 1 Related Classifications
HY-180277 Related Classifications
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