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Referencia número: HY-180280

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KLHDC2 ligand 3

KLHDC2 ligand 3 is an E3 ligase ligand. KLHDC2 ligand 3 can be used for the synthesis of PROTAC CDK6 Degrader 1 (HY-180277).

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Fòrmula: C₂₂H₂₅N₅O₃
Peso molecular:407.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KLHDC2 ligand 3 Chemical Structure

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Descripciòn

KLHDC2 ligand 3 is an E3 ligase ligand. KLHDC2 ligand 3 can be used for the synthesis of PROTAC CDK6 Degrader 1 (HY-180277)^[1].

IC₅₀ & Target^[1]

KLHDC2

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Chemical Information

Peso molecular 407.47
Fòrmula C₂₂H₂₅N₅O₃
SMILES

O=C([C@@H]1CN(CCC1)C2=C3C=CC=CC3=CN=C2)NCC4=CN(N=C4)CC(OC)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jeon E, et al. Selective CDK6 Degradation via the KLHDC2 E3 Ubiquitin Ligase. J Med Chem. 2025 Dec 11;68(23):25539-25568. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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KLHDC2 ligand 3

Ver todos los productos específicos de isoformas Ligands for E3 Ligase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

KLHDC2 ligand 3 Related Classifications

HY-180280 Related Classifications