CDK6 ligand 1
CDK6 ligand 1 is a CDK6 ligand that can be used in studies related to PROTAC synthesis, for example, acting as the target protein ligand of PROTAC CDK6 Degrader 1 (HY-180277).
For research use only. We do not sell to patients.
- Formula: C30H38N8O3
- Molecular Weight:558.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CDK6 |
In Vitro
CDK6 ligand 1 acts as the target protein ligand for PROTAC CDK6 Degrader 1 (HY-180277). PROTAC CDK6 Degrader 1 (compound 48a) is a highly potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. It induces G0/G1 phase cell cycle arrest and apoptosis by inhibiting the downstream signaling pathways of CDK6, and can be applied in research on CDK6-driven cancers such as acute leukemia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 558.67
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Formula C30H38N8O3
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SMILES
CC(C1=C(C)C(C(N(C1=O)C2CCCC2)=N3)=CN=C3NC(C=C4)=NC=C4N5CCN(CC5)C(C6CCNCC6)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK6 ligand 1 Related Classifications
HY-180278 Related Classifications
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