Dalpiciclib isethionate
Based on 2 publication(s) in Google Scholar
Dalpiciclib (isethionate) is a CDK4/6 inhibitor. Dalpiciclib (isethionate) inhibits the kinase activity of CDK4 and CDK6, thereby blocking the G1-to-S phase transition of the cell cycle and suppressing abnormal cell proliferation. Dalpiciclib (isethionate) can be used for the study of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 1980822-14-7
- Formula: C27H36N6O6S
- Molecular Weight:572.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Dalpiciclib isethionate
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Cell Proliferation/Viability Assay
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Biological Activity
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CDK4 |
CDK6 |
Chemical Information
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CAS No. 1980822-14-7
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Molecular Weight 572.68
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Formula C27H36N6O6S
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SMILES
O=C1C(C(C)=O)=C(C)C2=C(N1C3CCCC3)N=C(NC4=NC=C(C5CCNCC5)C=C4)N=C2.O=S(O)(CCO)=O
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Synonyms
SHR-6390 isethionate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication. [Abstract]2026 Jun 5. PMID: 42248826
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
22Rv1 and C4-2B cells were treated for 48 h with ENZ and DAL in a fixed-ratio combination (10:1), with 2-fold serial dilutions of ENZ (10–160 μM) and Dalpiciclib (DAL) (1–16 μM).
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative images of colony formation assays in 22Rv1 and C4-2B cells treated with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination for 12–17 days.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative immunofluorescence images of BrdU incorporation assays in 22Rv1 and C4-2B cells treated with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination for 48 h.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative Annexin V/PI flow cytometry plots showing apoptosis in 22Rv1 and C4-2B cells after 48-hour treatment with Control (DMSO), ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or their combination.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Western blot analysis of cell cycle-related proteins in 22Rv1 and C4-2B cells treated with or without ENZ (35 μM) and/or Dalpiciclib (DAL) (2 μM) for 48 h.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Representative images of wound-healing assays conducted on 22Rv1 and C4-2B cells treated with DMSO, ENZ (35 μM), Dalpiciclib (DAL) (2 μM), or ENZ (35 μM) + DAL (2 μM) for 24 h.
Dalpiciclib isethionate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jun 5. [Abstract]
Bioluminescence imaging and representative photographs of excised popliteal lymph nodes from nude mice at the experimental endpoint (day 28) treated with Dalpiciclib (DAL) (75 mg/kg, i.g.).
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dalpiciclib isethionate Related Classifications
HY-114338B Related Classifications
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