2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Epigenetics
  3. Epigenetic Reader Domain CDK PI3K
  4. SRX3177

SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells.

For research use only. We do not sell to patients.

SRX3177 Chemical Structure

SRX3177 Chemical Structure

CAS No. : 2241237-51-2

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 579 In-stock
Solution
10 mM * 1 mL in DMSO USD 579 In-stock
Solid
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10 mg USD 720 In-stock
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Based on 1 publication(s) in Google Scholar

SRX3177 Related Antibodies

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Description

SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells[1].

Molecular Weight

584.69

Formula

C31H32N6O4S
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(NC5=NC6=C(C=C(N6C7CCCC7)C(N(C)C)=O)C=N5)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (42.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7103 mL 8.5515 mL 17.1031 mL
5 mM 0.3421 mL 1.7103 mL 3.4206 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.59%

COA (252 KB) HNMR (417 KB) RP-HPLC (245 KB) MS (72 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7103 mL 8.5515 mL 17.1031 mL 42.7577 mL
5 mM 0.3421 mL 1.7103 mL 3.4206 mL 8.5515 mL
10 mM 0.1710 mL 0.8552 mL 1.7103 mL 4.2758 mL
15 mM 0.1140 mL 0.5701 mL 1.1402 mL 2.8505 mL
20 mM 0.0855 mL 0.4276 mL 0.8552 mL 2.1379 mL
25 mM 0.0684 mL 0.3421 mL 0.6841 mL 1.7103 mL
30 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
40 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0689 mL
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SRX3177 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRX31772241237-51-2SRX 3177SRX-3177Epigenetic Reader DomainCDKPI3KCyclin dependent kinasePhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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