2. Cell Cycle/DNA Damage NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. CDK Reactive Oxygen Species (ROS) SOD
  4. CDK4/6-IN-26

CDK4/6-IN-26 is a carbamate derivative that targets CDK4/CDK6. CDK4/6-IN-26 reduces CDK4/CDK6 levels, resulting in cell cycle arrest in the G0/G1 phase and in the S phase. CDK4/6-IN-26 exhibits high potency against SW480 cells (IC50 = 6.3 μM). CDK4/6-IN-26 affects ROS levels by increasing the expression of SOD2/MnSOD. CDK4/6-IN-26 establishes several interactions with the amino acids of the CDK6 active site. CDK4/6-IN-26 can be used for the research of colorectal cancer.

For research use only. We do not sell to patients.

CDK4/6-IN-26

CDK4/6-IN-26 Chemical Structure

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CDK4/6-IN-26 Related Antibodies

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Description

CDK4/6-IN-26 is a carbamate derivative that targets CDK4/CDK6. CDK4/6-IN-26 reduces CDK4/CDK6 levels, resulting in cell cycle arrest in the G0/G1 phase and in the S phase. CDK4/6-IN-26 exhibits high potency against SW480 cells (IC50 = 6.3 μM). CDK4/6-IN-26 affects ROS levels by increasing the expression of SOD2/MnSOD. CDK4/6-IN-26 establishes several interactions with the amino acids of the CDK6 active site. CDK4/6-IN-26 can be used for the research of colorectal cancer[1].

IC50 & Target[1]

CDK4

 

CDK6

 

In Vitro

CDK4/6-IN-26 (compound 17) (6.3 μM; 72 h; SW480) affectes the growth pattern of SW480 cells by increasing the cell doubling time, consequently decreasing the cell growth rate[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) shows cell cycle arrest at G0/G1 phase at 24 h and S phase at 48 h. And at 72 h, CDK4/6-IN-26 has no impact on the cell cycle of SW480 cells[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) decreases CDK4/6, cyclin A, and Rb protein levels and increases SOD2/MnSOD expression[1].
CCDK4/6-IN-26 (72 h) inhibits cell viability of SW480, SW620, HCT116, Caco-2, Mia Paca-2 and A375 cells with IC50 values of 6.3 μM, 10 μM, 17 μM, 16 μM, 7.5 μM, and 6.7 μM, respectively. CDK4/6-IN-26 does not affect the proliferation of normal cells[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) does not induce apoptosis in the SW480 cells[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) reduces ROS levels at 24 h and increases ROS levels at 48-72 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK4/6-IN-26 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SW480 cells
Concentration: 6.3 μM
Incubation Time: 24, 48 or 72 h
Result: Affected the growth pattern of SW480 cells by increasing the cell doubling time, consequently decreasing the cell growth rate.

Cell Cycle Analysis[1]

Cell Line: SW480
Concentration: 6.3 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Induced cell cycle arrest at the G0/G1 phase at 24 h and in the S phase at 48 h

Western Blot Analysis[1]

Cell Line: SW480
Concentration: 6.3 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Decreased levels of CDK4/6 proteins and cyclin A at 24 h and 48 h, and decreased Rb protein levels at all time points Increased expression of SOD2/MnSOD at 24 h and 72 h.
Molecular Weight

487.63

Formula

C28H41NO6
SMILES

CC(C1=C(OC(C)=O)C(OC(C)=O)=C2[C@@]3(NC(OCC(C)C)=O)CCCC(C)(C)[C@]3([H])CCC2=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK4/6-IN-26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK4/6-IN-26CDKReactive Oxygen Species (ROS)SODCyclin dependent kinaseSuperoxide DismutaseCDK6,CDK4,colorectal cancer,SOD2/MnSOD,ROSInhibitorinhibitorinhibit

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