CDK4/6-IN-26

CDK4/6-IN-26 (compound 17) (6.3 μM; 72 h; SW480) affectes the growth pattern of SW480 cells by increasing the cell doubling time, consequently decreasing the cell growth rate^[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) shows cell cycle arrest at G0/G1 phase at 24 h and S phase at 48 h. And at 72 h, CDK4/6-IN-26 has no impact on the cell cycle of SW480 cells^[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) decreases CDK4/6, cyclin A, and Rb protein levels and increases SOD2/MnSOD expression^[1].
CCDK4/6-IN-26 (72 h) inhibits cell viability of SW480, SW620, HCT116, Caco-2, Mia Paca-2 and A375 cells with IC₅₀ values of 6.3 μM, 10 μM, 17 μM, 16 μM, 7.5 μM, and 6.7 μM, respectively. CDK4/6-IN-26 does not affect the proliferation of normal cells^[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) does not induce apoptosis in the SW480 cells^[1].
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) reduces ROS levels at 24 h and increases ROS levels at 48-72 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.