CDK4/6/HDAC-IN-1
CDK4/6/HDAC-IN-1 (Compound N14) is a dual-targeting inhibitor of CDK4/6 and HDAC (IC50: CDK4 = 7.23 nM, CDK6 = 13.20 nM, HDAC1 = 55.66 nM, HDAC6 = 48.38 nM). CDK4/6/HDAC-IN-1 induces cell Apoptosis and G0/G1 phase arrest through HDAC-p21-CDK signaling pathway. CDK4/6/HDAC-IN-1 inhibits hepatocellular carcinoma.
For research use only. We do not sell to patients.
- Formula: C35H39N9O5
- Molecular Weight:665.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK4 7.23 nM (IC50) |
CDK6 13.2 nM (IC50) |
CDK1 55.6 nM (IC50) |
CDK6 48.38 nM (IC50) |
Chemical Information
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Molecular Weight 665.74
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Formula C35H39N9O5
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SMILES
O=C(NO)/C=C/C1=CC=C(NC(CN2CCN(C3=CC=C(NC4=NC=C5C(N(C6CCCC6)C(C(C(C)=O)=C5C)=O)=N4)N=C3)CC2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK4/6/HDAC-IN-1 Related Classifications
HY-170651 Related Classifications
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