GFB-12811
Based on 1 publication(s) in Google Scholar
GFB-12811 is a high selective CDK5 inhibitor with an IC50 of 2.3 nM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.04%
- CAS. Nr.: 2775311-17-4
- Formel: C22H23F4N5O
- Molecular Weight:449.44
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) GFB-12811
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Cdk5/p25 2.3 nM (IC50) |
CDK2/CycA 211 nM (IC50) |
CDK7/Cyclin H/MAT1 718 nM (IC50) |
CDK9/CycT1 894 nM (IC50) |
CDK6 3197 nM (IC50) |
In Vitro
GFB-12811 exhibits a good metabolic stability and a low clearance in mouse hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2775311-17-4
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Appearance Solid
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Molecular Weight 449.44
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Formel C22H23F4N5O
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Color Light yellow to yellow
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SMILES
CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Res Sq
Cyclin-Dependent Kinase 5 Contributes to Bruton's Tyrosine Kinase Inhibitor Resistance via the IRE1α/XBP1 Axis in Mantle Cell Lymphoma. [Abstract]2026 May 8:rs.3.rs-9500406. PMID: 42147166
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (111.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2250 mL | 11.1250 mL | 22.2499 mL | 55.6248 mL |
| 5 mM | 0.4450 mL | 2.2250 mL | 4.4500 mL | 11.1250 mL | |
| 10 mM | 0.2225 mL | 1.1125 mL | 2.2250 mL | 5.5625 mL | |
| 15 mM | 0.1483 mL | 0.7417 mL | 1.4833 mL | 3.7083 mL | |
| 20 mM | 0.1112 mL | 0.5562 mL | 1.1125 mL | 2.7812 mL | |
| 25 mM | 0.0890 mL | 0.4450 mL | 0.8900 mL | 2.2250 mL | |
| 30 mM | 0.0742 mL | 0.3708 mL | 0.7417 mL | 1.8542 mL | |
| 40 mM | 0.0556 mL | 0.2781 mL | 0.5562 mL | 1.3906 mL | |
| 50 mM | 0.0445 mL | 0.2225 mL | 0.4450 mL | 1.1125 mL | |
| 60 mM | 0.0371 mL | 0.1854 mL | 0.3708 mL | 0.9271 mL | |
| 80 mM | 0.0278 mL | 0.1391 mL | 0.2781 mL | 0.6953 mL | |
| 100 mM | 0.0222 mL | 0.1112 mL | 0.2225 mL | 0.5562 mL |
GFB-12811 Related Classifications
HY-144117 Related Classifications
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