2. Cell Cycle/DNA Damage
  3. CDK
  4. GFB-12811

GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9).

For research use only. We do not sell to patients.

GFB-12811 Chemical Structure

GFB-12811 Chemical Structure

CAS No. : 2775311-17-4

Size Price Stock Quantity
5 mg USD 950 In-stock
10 mg USD 1500 In-stock
25 mg USD 3050 In-stock
50 mg USD 4850 In-stock
100 mg USD 7800 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

GFB-12811 Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9)[1].

IC50 & Target[1]

Cdk5/p25

2.3 nM (IC50)

CDK2/CycA

211 nM (IC50)

CDK7/Cyclin H/MAT1

718 nM (IC50)

CDK9/CycT1

894 nM (IC50)

Molecular Weight

449.44

Formula

C22H23F4N5O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2250 mL 11.1250 mL 22.2499 mL
5 mM 0.4450 mL 2.2250 mL 4.4500 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2250 mL 11.1250 mL 22.2499 mL 55.6248 mL
5 mM 0.4450 mL 2.2250 mL 4.4500 mL 11.1250 mL
10 mM 0.2225 mL 1.1125 mL 2.2250 mL 5.5625 mL
15 mM 0.1483 mL 0.7417 mL 1.4833 mL 3.7083 mL
20 mM 0.1112 mL 0.5562 mL 1.1125 mL 2.7812 mL
25 mM 0.0890 mL 0.4450 mL 0.8900 mL 2.2250 mL
30 mM 0.0742 mL 0.3708 mL 0.7417 mL 1.8542 mL
40 mM 0.0556 mL 0.2781 mL 0.5562 mL 1.3906 mL
50 mM 0.0445 mL 0.2225 mL 0.4450 mL 1.1125 mL
60 mM 0.0371 mL 0.1854 mL 0.3708 mL 0.9271 mL
80 mM 0.0278 mL 0.1391 mL 0.2781 mL 0.6953 mL
100 mM 0.0222 mL 0.1112 mL 0.2225 mL 0.5562 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GFB-12811 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GFB-128112775311-17-4GFB12811GFB 12811CDKCyclin dependent kinaseselectiveoralADPKDautosomal dominant polycystic kidney diseaseCDK5Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GFB-12811
Cat. No.:
HY-144117
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.