2. Cell Cycle/DNA Damage
  3. CDK
  4. GFB-12811

GFB-12811 

Cat. No.: HY-144117 Purity: 98.00% ee.: 99.68%
COA Handling Instructions

GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9).

For research use only. We do not sell to patients.

GFB-12811 Chemical Structure

GFB-12811 Chemical Structure

CAS No. : 2775311-17-4

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5 mg USD 950 In-stock
10 mg USD 1500 In-stock
25 mg USD 3050 In-stock
50 mg USD 4850 In-stock
100 mg USD 7800 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GFB-12811:

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • Biological Activity

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Description

GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9)[1].

IC50 & Target[1]

Cdk5/p25

2.3 nM (IC50)

CDK2/CycA

211 nM (IC50)

CDK7/Cyclin H/MAT1

718 nM (IC50)

CDK9/CycT1

894 nM (IC50)

Molecular Weight

449.44

Appearance

Solid

Formula

C22H23F4N5O
CAS No.
SMILES

CN1CCC(CC1)[[email protected]@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2250 mL 11.1250 mL 22.2499 mL
5 mM 0.4450 mL 2.2250 mL 4.4500 mL
10 mM 0.2225 mL 1.1125 mL 2.2250 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

GFB-128112775311-17-4GFB12811GFB 12811CDKCyclin dependent kinaseselectiveoralADPKDautosomal dominant polycystic kidney diseaseCDK5Inhibitorinhibitorinhibit

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