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CDK6/9-IN-2

CDK6/9-IN-2 is a highly active dual inhibitor of CDK6 (IC₅₀ = 15 nM) and CDK9 (IC₅₀ = 22 nM). CDK6/9-IN-2 is selective for CDK2, CDK8, and CDK11. CDK6/9-IN-2 inhibits the proliferation of HaCaT cells induced by IFN-γ/TNF-α and suppresses the STAT3 pathway and the expression of inflammatory factors. CDK6/9-IN-2 can alleviate psoriatic dermatitis and is useful in psoriasis research.

For research use only. We do not sell to patients.

CAS No.: 3068529-24-5
Formula: C₂₅H₃₀ClN₇O
Molecular Weight:480.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CDK6/9-IN-2 Chemical Structure

CAS No.: 3068529-24-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

CDK6

15 nM (IC₅₀)

CDK9

22 nM (IC₅₀)

STAT3

IL-6

IL-1β

IL-8

All CDK Isoforms :

All STAT Isoforms :

All Interleukin Related Isoforms :

In Vitro

CDK6/9-IN-2 (Compound 4) (0.0032-2 μM, 2 + 24 h) can effectively inhibit cell proliferation at 80 nM in IFN-γ/TNF-α induced HaCaT cells^[1].
CDK6/9-IN-2 (0.1-1 μM, 24 h) inhibits the STAT3 pathway and the expression of inflammatory factors to improve inflammatory damage to skin cells in IFN-γ/TNF-α induced HaCaT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

IFN-γ/TNF-α (2 ng/ml, 24 h) induced HaCaT cells
Concentration:

0.1 μM, 0.4 μM, 1 μM,
Incubation Time:

24 h
Result:

Inhibited the phosphorylation of STAT3 and the secretion of various inflammatory factors (including IL-1β, IL-6 and IL-8).

RT-PCR^[1]

Cell Line:

IFN-γ/TNF-α (2 ng/ml, 24 h) induced HaCaT cells
Concentration:

0.1 μM, 0.4 μM, 1 μM,
Incubation Time:

24 h
Result:

Inhibited IL-1β, IL-6 and IL-8 mRNA levels.

Chemical Information

CAS No. 3068529-24-5
Molecular Weight 480.01
Formula C₂₅H₃₀ClN₇O
SMILES

CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(NC4=CC=C(C=C4)N5CC[C@@H](C5)O)=N3)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ru Y, et al. Dual CDK6 and CDK9 inhibitors as anti-psoriasis agents: Design, synthesis, and anti-inflammatory activity. Bioorg Med Chem Lett. 2025 Nov 1;127:130316. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CDK6/9-IN-2

All CDK Isoforms

All STAT Isoforms

All Interleukin Related Isoforms