CDK6/9-IN-2
CDK6/9-IN-2 is a highly active dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM). CDK6/9-IN-2 is selective for CDK2, CDK8, and CDK11. CDK6/9-IN-2 inhibits the proliferation of HaCaT cells induced by IFN-γ/TNF-α and suppresses the STAT3 pathway and the expression of inflammatory factors. CDK6/9-IN-2 can alleviate psoriatic dermatitis and is useful in psoriasis research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3068529-24-5
- 分子式: C25H30ClN7O
- 分子量:480.01
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
CDK6 15 nM (IC50) |
CDK9 22 nM (IC50) |
STAT3 |
IL-6 |
IL-1β |
IL-8 |
体外実験
CDK6/9-IN-2 (Compound 4) (0.0032-2 μM, 2 + 24 h) can effectively inhibit cell proliferation at 80 nM in IFN-γ/TNF-α induced HaCaT cells[1].
CDK6/9-IN-2 (0.1-1 μM, 24 h) inhibits the STAT3 pathway and the expression of inflammatory factors to improve inflammatory damage to skin cells in IFN-γ/TNF-α induced HaCaT cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IFN-γ/TNF-α (2 ng/ml, 24 h) induced HaCaT cells
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Concentration:0.1 μM, 0.4 μM, 1 μM,
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Incubation Time:24 h
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Result:Inhibited the phosphorylation of STAT3 and the secretion of various inflammatory factors (including IL-1β, IL-6 and IL-8).
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Cell Line:IFN-γ/TNF-α (2 ng/ml, 24 h) induced HaCaT cells
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Concentration:0.1 μM, 0.4 μM, 1 μM,
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Incubation Time:24 h
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Result:Inhibited IL-1β, IL-6 and IL-8 mRNA levels.
化学情報
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CAS 番号 3068529-24-5
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分子量 480.01
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分子式 C25H30ClN7O
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SMILES
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(NC4=CC=C(C=C4)N5CC[C@@H](C5)O)=N3)Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDK6/9-IN-2 関連分類
HY-175013 関連分類
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