3068529-24-5
3068529-24-5
Chemical Structure
CDK6/9-IN-2
- CAS No.: 3068529-24-5
- Formula:C25H30ClN7O
- Molecular Weight:480.01
SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(NC4=CC=C(C=C4)N5CC[C@@H](C5)O)=N3)Cl
Biological Activity: CDK6/9-IN-2 is a highly active dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM). CDK6/9-IN-2 is selective for CDK2, CDK8, and CDK11. CDK6/9-IN-2 inhibits the proliferation of HaCaT cells induced by IFN-γ/TNF-α and suppresses the STAT3 pathway and the expression of inflammatory factors. CDK6/9-IN-2 can alleviate psoriatic dermatitis and is useful in psoriasis research[1].
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CDK6/9-IN-2 | CDK6/9-IN-2 is a highly active dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM). CDK6/9-IN-2 is selective for CDK2, CDK8, and CDK11. CDK6/9-IN-2 inhibits the proliferation of HaCaT cells induced by IFN-γ/TNF-α and suppresses the STAT3 pathway and the expression of inflammatory factors. CDK6/9-IN-2 can alleviate psoriatic dermatitis and is useful in psoriasis research. | |||||||||||||||||||||
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References
Keywords
