2. Cell Cycle/DNA Damage
    Apoptosis
  3. CDK
    Apoptosis
  4. CDK9-IN-7

CDK9-IN-7 

Cat. No.: HY-126251 Purity: 99.81%
COA Handling Instructions

CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC.

For research use only. We do not sell to patients.

CDK9-IN-7 Chemical Structure

CDK9-IN-7 Chemical Structure

CAS No. : 2369981-71-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 693 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 693 In-stock
Solid
5 mg USD 630 In-stock
10 mg USD 980 In-stock
50 mg USD 2800 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC[1].

IC50 & Target[1]

CDK9/cyclinT1

11 nM (IC50)

CDK4/cyclin D

148 nM (IC50)

CDK6/cyclinD

145 nM (IC50)

In Vitro

CDK9-IN-7 displays exceptional potency against NSCLC cell lines, especial A549 and H1299 with IC50 values less than 0.5 µM. In the drug-resistant NSCLC cell line H1975, CDK9-IN-7 also exhibits good inhibition potency with an IC50 value of 0.837 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

547.71

Appearance

Solid

Formula

C29H37N7O2S
CAS No.
SMILES

O=C(N(C)C)C1=CC2=CN=C(NC3=CC=C(NC(CCCCCCCN=C=S)=O)C=C3)N=C2N1C4CCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (114.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8258 mL 9.1289 mL 18.2578 mL
5 mM 0.3652 mL 1.8258 mL 3.6516 mL
10 mM 0.1826 mL 0.9129 mL 1.8258 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.80 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.81%

COA (246 KB) HNMR (207 KB) LCMS (119 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CDK9-IN-72369981-71-3CDKApoptosisCyclin dependent kinaseInhibitorinhibitorinhibit

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