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APOBEC1 - apolipoprotein B mRNA editing enzyme catalytic subunit 1 Gene

Also Known as BEDP; HEPR; CDAR1; APOBEC-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 339

About APOBEC1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,649,400-7,670,599 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues and 9 paralogues. Biased expression in duodenum (RPKM 22.2), small intestine (RPKM 18.5) and 1 other tissue.

Summary

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide Bases in Apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

APOBEC1 Products (3)

mRNA	Protein	Name
NM_001304566.1	NP_001291495.1	C->U-editing enzyme APOBEC-1 isoform a
NM_001644.5	NP_001635.2	C->U-editing enzyme APOBEC-1 isoform a
NM_005889.4	NP_005880.2	C->U-editing enzyme APOBEC-1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10669759	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytidine to uridine editing	IDA IDA: Inferred from direct assay	24916387	GOA
involved in mRNA modification	IDA IDA: Inferred from direct assay	11134005	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	12881431	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of apolipoprotein B mRNA editing enzyme complex	IDA IDA: Inferred from direct assay	24916387	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22580899	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12881431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC1 Protein Structure

APOBEC_N

0
100
200
236 a.a.

Protein Preferred Names	Protein Names
C->U-editing enzyme APOBEC-1	apolipoprotein B mRNA editing enzyme complex-1

APOBEC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOBEC1	P41238	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	APOBEC1	P41238	UFSP2	Homo sapiens	Q9NUQ7	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	APOBEC1	P41238	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	APOBEC1	P41238	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	APOBEC1	P41238	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	NOTO	Homo sapiens	A8MTQ0	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	NOTO	Homo sapiens	A8MTQ0	Y2H Array	32296183
Intra	APOBEC1	P41238	CDK6	Homo sapiens	Q00534	Validated Y2H	32296183
Intra	APOBEC1	P41238	HNRNPF	Homo sapiens	P52597	Validated Y2H	32296183
Intra	APOBEC1	P41238	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	APOBEC1	P41238	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	APOBEC1	P41238	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Immunodeficiency With Hyper-Igm, Type 2	HIGM2 Hyper-Igm Syndrome Type 2 Hyper-Igm Syndrome 2 Immunodeficiency With Hyper-Igm Type 2 Activation-Induced Cytidine Deaminase Deficiency Aid Deficiency Immunodeficiency With Hyper Igm Type 2 Hyper Igm Syndrome 2 Immunodeficiency With Hyper-Igm 2 Hyper-Igm Immunodeficiency Type 2 Immunodeficiency, With Hyper Igm, Type 2 Hyper-Igm Immunodeficiency Syndrome, Type 2
Immunodeficiency With Hyper-Igm, Type 1	Immunodeficiency, X-Linked, With Hyper-Igm Hyper Igm Syndrome HIGM1 Xhim Hyper-Igm Syndrome Higm Hyper-Igm Syndrome 1 Immunodeficiency 3 Imd3 Immunodeficiency With Hyper-Igm Immunodeficiency With Hyper Igm Type 1 Ihis X-Linked Hyper Igm Syndrome Hyper-Igm Immunodeficiency, X-Linked Hyper Igm Immunodeficiency, X-Linked Hyper Igm Syndrome 1 X-Linked Immunodeficiency With Hyper-Igm 1 Immunodeficiency, With Hyper Igm Immunodeficiency, With Hyper Igm, Type 1 Hyper-Igm Immunodeficiency Syndrome, Type 1 Hyperimmunoglobulin M Syndrome
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00834	APOBEC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC1	MGD	MGI:103298
Bos taurus	APOBEC1	VGNC	VGNC:26027
Rattus norvegicus	APOBEC1	RGD	RGD:2133
Canis familiaris	APOBEC1	VGNC	VGNC:37995
Others	APOBEC1	NCBI