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NOTO - notochord homeobox Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 344022

About NOTO

This gene has 1 transcript (splice variant), 90 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic organ development; motile cilium assembly; and regulation of cilium assembly. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NOTO Products (1)

mRNA	Protein	Name
NM_001134462.2	NP_001127934.1	homeobox protein notochord

NOTO Protein Structure

Homeobox

0
100
200
251 a.a.

Protein Preferred Names	Protein Names
homeobox protein notochord	notochord homolog

NOTO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOTO	A8MTQ0	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	CHAF1A	Homo sapiens	Q13111	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	NOTO	A8MTQ0	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	NOTO	A8MTQ0	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	KRT34	Homo sapiens	O76011	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	BTF3	Homo sapiens	P20290-2	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	EIPR1	Homo sapiens	Q53HC9	Y2H Prey Pooling	32296183
Intra	NOTO	A8MTQ0	EIPR1	Homo sapiens	Q53HC9	Y2H Array	32296183
Intra	NOTO	A8MTQ0	EIPR1	Homo sapiens	Q53HC9	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	IP6K3	Homo sapiens	Q96PC2	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	NOTO	A8MTQ0	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	NOTO	A8MTQ0	APOBEC1	Homo sapiens	P41238	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	SBK3	Homo sapiens	P0C264	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	UBTFL1	Homo sapiens	P0CB47	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	POU4F2	Homo sapiens	Q12837	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	FOXD2	Homo sapiens	O60548	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	ETV3L	Homo sapiens	Q6ZN32	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	FOXH1	Homo sapiens	O75593	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	LRP10	Homo sapiens	Q7Z4F1	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	CEP19	Homo sapiens	Q96LK0	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	BAG3	Homo sapiens	O95817	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	LDLRAP1	Homo sapiens	Q5SW96	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	GLYCTK	Homo sapiens	Q8IVS8	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	MEIS2	Homo sapiens	O14770-4	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	NOTO	A8MTQ0	NKX2-4	Homo sapiens	Q9H2Z4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Epilepsy, Familial Temporal Lobe, 4	ETL4 Epilepsy, Occipitotemporal Lobe, And Migraine With Aura Epolm Familial Temporal Lobe Epilepsy 4 Occipitotemporal Lobe Epilepsy And Migraine With Aura

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09453	NOTO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NOTO	RGD	RGD:1562910
Macaca mulatta	NOTO	VGNC	VGNC:106189
Bos taurus	NOTO	VGNC	VGNC:32180
Mus musculus	NOTO	MGD	MGI:3053002
Others	NOTO	NCBI