FOXH1 - forkhead box H1 Gene
Also Known as FAST1; FAST-1
Species: Homo sapiens
About FOXH1
This gene has 2 transcripts (splice variants), 192 orthologues, 42 paralogues and is associated with 6 phenotypes. Broad expression in skin (RPKM 10.3), brain (RPKM 5.3) and 22 other tissues.
Summary
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]
FOXH1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003923.3 | NP_003914.1 | forkhead box protein H1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| contributes to DNA binding |
IDA
IDA: Inferred from direct assay
|
9389648 | GOA |
| contributes to DNA-binding transcription factor activity |
IDA
IDA: Inferred from direct assay
|
17438144 | GOA |
| enables DNA-binding transcription factor binding |
IPI
IPI: Inferred from physical interaction
|
18922797 | GOA |
| enables R-SMAD binding |
IMP
IMP: Inferred from mutant phenotype
|
16120611 | GOA |
| enables R-SMAD binding |
IPI
IPI: Inferred from physical interaction
|
9389648 | GOA |
| enables SMAD binding |
IPI
IPI: Inferred from physical interaction
|
21828274 | GOA |
| enables bHLH transcription factor binding |
IPI
IPI: Inferred from physical interaction
|
21828274 | GOA |
| enables co-SMAD binding |
IMP
IMP: Inferred from mutant phenotype
|
16120611 | GOA |
| enables nuclear androgen receptor binding |
IPI
IPI: Inferred from physical interaction
|
16120611 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9702198 | GOA |
| enables protein domain specific binding |
IPI
IPI: Inferred from physical interaction
|
9702198 | GOA |
| enables sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
9702198 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cellular response to cytokine stimulus |
IMP
IMP: Inferred from mutant phenotype
|
14671321 | GOA |
| involved in negative regulation of DNA-binding transcription factor activity |
IDA
IDA: Inferred from direct assay
|
16120611 | GOA |
| involved in negative regulation of androgen receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
16120611 | GOA |
| involved in negative regulation of intracellular estrogen receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
16120611 | GOA |
| involved in positive regulation of DNA-templated transcription |
IDA
IDA: Inferred from direct assay
|
9389648 | GOA |
| involved in positive regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
9702198 | GOA |
| involved in positive regulation of transcription by RNA polymerase II |
IMP
IMP: Inferred from mutant phenotype
|
14671321 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of activin responsive factor complex |
IDA
IDA: Inferred from direct assay
|
9389648 | GOA |
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
21828274 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
16120611 | GOA |
| part of transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
17438144 | GOA |
FOXH1 Protein Structure
Forkhead: Forkhead domain (33 - 114)
- 0
- 100
- 200
- 300
- 365 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
forkhead box protein H1 |
|
FOXH1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FOXH1 | O75593 | PNMA5 | Homo sapiens | Q96PV4 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TEKT5 | Homo sapiens | Q96M29 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TEKT5 | Homo sapiens | Q96M29 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TEKT5 | Homo sapiens | Q96M29 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP13-3 | Homo sapiens | Q3SY46 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP13-3 | Homo sapiens | Q3SY46 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP13-3 | Homo sapiens | Q3SY46 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SMAD2 | Homo sapiens | Q15796 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SMAD2 | Homo sapiens | Q15796 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SMAD2 | Homo sapiens | Q15796 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ZIC1 | Homo sapiens | Q15915 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | RBPMS2 | Homo sapiens | Q6ZRY4 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | RBPMS2 | Homo sapiens | Q6ZRY4 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | RBPMS2 | Homo sapiens | Q6ZRY4 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HSF4 | Homo sapiens | Q9ULV5-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HSF4 | Homo sapiens | Q9ULV5-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HSF4 | Homo sapiens | Q9ULV5-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | UFSP1 | Homo sapiens | Q6NVU6 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | UFSP1 | Homo sapiens | Q6NVU6 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | UFSP1 | Homo sapiens | Q6NVU6 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | RBM46 | Homo sapiens | Q8TBY0 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | RBM46 | Homo sapiens | Q8TBY0 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | RBM46 | Homo sapiens | Q8TBY0 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | FAM168B | Homo sapiens | A1KXE4-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | FAM168B | Homo sapiens | A1KXE4-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-2 | Homo sapiens | Q3LHN2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-2 | Homo sapiens | Q3LHN2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-2 | Homo sapiens | Q3LHN2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-6 | Homo sapiens | Q3LI70 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-6 | Homo sapiens | Q3LI70 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP19-6 | Homo sapiens | Q3LI70 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TSC1 | Homo sapiens | Q86WV8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TSC1 | Homo sapiens | Q86WV8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TSC1 | Homo sapiens | Q86WV8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | C10orf55 | Homo sapiens | Q5SWW7 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | C10orf55 | Homo sapiens | Q5SWW7 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | C10orf55 | Homo sapiens | Q5SWW7 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | AOC1 | Homo sapiens | P19801 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | AOC1 | Homo sapiens | P19801 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | AOC1 | Homo sapiens | P19801 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | FAM83A | Homo sapiens | Q86UY5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | FAM83A | Homo sapiens | Q86UY5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | FAM83A | Homo sapiens | Q86UY5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | NOTO | Homo sapiens | A8MTQ0 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | NOTO | Homo sapiens | A8MTQ0 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP7-1 | Homo sapiens | Q8IUC3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP7-1 | Homo sapiens | Q8IUC3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP7-1 | Homo sapiens | Q8IUC3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | UBAP2 | Homo sapiens | Q5T6F2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SMAD3 | Homo sapiens | P84022 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SMAD3 | Homo sapiens | P84022 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SMAD3 | Homo sapiens | P84022 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TFG | Homo sapiens | Q92734 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | NCK1 | Homo sapiens | P16333 | 17474147 | |
|
Intra
|
FOXH1 | O75593 | TLX3 | Homo sapiens | O43711 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TLX3 | Homo sapiens | O43711 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CEACAM6 | Homo sapiens | P40199 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CEACAM6 | Homo sapiens | P40199 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CEACAM6 | Homo sapiens | P40199 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SERGEF | Homo sapiens | Q9UGK8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SERGEF | Homo sapiens | Q9UGK8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SERGEF | Homo sapiens | Q9UGK8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | PPP1R37 | Homo sapiens | O75864 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | AR | Homo sapiens | P10275 | 16120611 | |
|
Intra
|
FOXH1 | O75593 | MSX2 | Homo sapiens | P35548 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | MSX2 | Homo sapiens | P35548 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | MSX2 | Homo sapiens | P35548 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HLX | Homo sapiens | Q14774 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HLX | Homo sapiens | Q14774 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HLX | Homo sapiens | Q14774 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CRYBA1 | Homo sapiens | P05813 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CRYBA1 | Homo sapiens | P05813 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CRYBA1 | Homo sapiens | P05813 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CFAP68 | Homo sapiens | Q9H5F2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CFAP68 | Homo sapiens | Q9H5F2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CFAP68 | Homo sapiens | Q9H5F2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TCF12 | Homo sapiens | Q99081 | 21828274 | |
|
Intra
|
FOXH1 | O75593 | HEY1 | Homo sapiens | Q9Y5J3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HEY1 | Homo sapiens | Q9Y5J3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HEY1 | Homo sapiens | Q9Y5J3 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KLHL26 | Homo sapiens | Q53HC5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KLHL26 | Homo sapiens | Q53HC5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HOXA1 | Homo sapiens | P49639 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ZC3H10 | Homo sapiens | Q96K80 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | BATF2 | Homo sapiens | Q8N1L9 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | BATF2 | Homo sapiens | Q8N1L9 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | BATF2 | Homo sapiens | Q8N1L9 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HDHD3 | Homo sapiens | Q9BSH5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HDHD3 | Homo sapiens | Q9BSH5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | HDHD3 | Homo sapiens | Q9BSH5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | TCF3 | Homo sapiens | P15923 | 21828274 | |
|
Intra
|
FOXH1 | O75593 | ATXN1L | Homo sapiens | P0C7T5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ATXN1L | Homo sapiens | P0C7T5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ATXN1L | Homo sapiens | P0C7T5 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ZNF503 | Homo sapiens | Q96F45 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ZNF503 | Homo sapiens | Q96F45 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ZNF503 | Homo sapiens | Q96F45 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SOX14 | Homo sapiens | O95416 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SOX14 | Homo sapiens | O95416 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | SOX14 | Homo sapiens | O95416 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | LASP1 | Homo sapiens | Q14847-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | LASP1 | Homo sapiens | Q14847-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | LASP1 | Homo sapiens | Q14847-2 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ARID5A | Homo sapiens | Q03989 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ARID5A | Homo sapiens | Q03989 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ARID5A | Homo sapiens | Q03989 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | ARID5A | Homo sapiens | Q03989 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32296183 | |
|
Intra
|
FOXH1 | O75593 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Septopreoptic Holoprosencephaly |
|
|
| Midline Interhemispheric Variant Of Holoprosencephaly |
|
|
| Microform Holoprosencephaly |
|
|
| Lobar Holoprosencephaly |
|
|
| Alobar Holoprosencephaly |
|
|
| Semilobar Holoprosencephaly |
|
|
| Holoprosencephaly |
|
|
| Acquired Hyperkeratosis |
|
|
| Friedreich Ataxia |
|
|
| Holoprosencephaly 4 |
|
|
| Transposition Of The Great Arteries, Dextro-Looped |
|
|
| Hypoplastic Right Heart Syndrome |
|
|
| Cardiomyopathy, Familial Hypertrophic, 3 |
|
|
| Holoprosencephaly 3 |
|
|
| Patau Syndrome |
|
|
| Double Outlet Right Ventricle |
|
|
| Hereditary Angioedema |
|
|
| Ventricular Septal Defect |
|
|
| Patent Ductus Arteriosus 1 |
|
|
| Visceral Heterotaxy |
|
|
| Tetralogy Of Fallot |
|
|
| Congenital Nervous System Abnormality |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | FOXH1 | MGD | MGI:1347465 |
| Rattus norvegicus | FOXH1 | RGD | RGD:1311275 |
| Felis catus | FOXH1 | VGNC | VGNC:62334 |
| Canis familiaris | FOXH1 | VGNC | VGNC:51772 |
| Bos taurus | FOXH1 | VGNC | VGNC:29086 |
| Macaca mulatta | FOXH1 | VGNC | VGNC:72699 |
| Others | FOXH1 | NCBI |