SERGEF - secretion regulating guanine nucleotide exchange factor Gene

Also Known as Gnefr; DELGEF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26297

About SERGEF

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,788,048-18,013,047 (from NCBI)

This gene has 23 transcripts (splice variants), 196 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 11.3), thyroid (RPKM 11.2) and 25 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in negative regulation of protein secretion. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SERGEF Products (1)

mRNA Protein Name
NM_012139.4 NP_036271.1 secretion-regulating guanine nucleotide exchange factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12459492 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein secretion IDA
IDA: Inferred from direct assay
12459492 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10571079 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10571079 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERGEF Protein Structure

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (17 - 64)

RCC1_2

RCC1_2: Regulator of chromosome condensation (RCC1) repeat (105 - 132)

RCC1_2

RCC1_2: Regulator of chromosome condensation (RCC1) repeat (219 - 243)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (284 - 348)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (351 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

secretion-regulating guanine nucleotide exchange factor

  • deafness locus associated putative guanine nucleotide exchange factor

SERGEF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERGEF Q9UGK8 DPH3 Homo sapiens Q96FX2
Y2H
14980502
Intra
SERGEF Q9UGK8 PRMT6 Homo sapiens Q96LA8
Anti Tag CoIP
23455924
Intra
SERGEF Q9UGK8 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Theileriasis

  • Theileriosis

  • Infection By Theileria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12689 SERGEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SERGEF RGD RGD:1563497
Felis catus SERGEF VGNC VGNC:81941
Mus musculus SERGEF MGD MGI:1351630
Bos taurus SERGEF VGNC VGNC:50043
Macaca mulatta SERGEF VGNC VGNC:77258
Others SERGEF NCBI