SERGEF - secretion regulating guanine nucleotide exchange factor Gene

Homo sapiens

Also known as Gnefr; DELGEF

Gene ID: 26297 | Gene type: protein coding

About SERGEF

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,788,048-18,013,047 (from NCBI)

This gene has 23 transcripts (splice variants), 196 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 11.3), thyroid (RPKM 11.2) and 25 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in negative regulation of protein secretion. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SERGEF Products(1)

mRNA	Protein	Name
NM_012139.4	NP_036271.1	secretion-regulating guanine nucleotide exchange factor

SERGEF Protein Structure

RCC1

RCC1_2

RCC1

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

secretion-regulating guanine nucleotide exchange factor

deafness locus associated putative guanine nucleotide exchange factor

Related Diseases

Diseases

Alias

Theileriasis

Theileriosis

Infection By Theileria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12689	SERGEF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SERGEF	RGD	RGD:1563497
Felis catus	SERGEF	VGNC	VGNC:81941
Mus musculus	SERGEF	MGD	MGI:1351630
Bos taurus	SERGEF	VGNC	VGNC:50043
Macaca mulatta	SERGEF	VGNC	VGNC:77258

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