TCF3 - transcription factor 3 Gene

Also Known as E2A; E47; p75; AGM8; ITF1; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6929

About TCF3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,609,292-1,652,615 (from NCBI)

This gene has 21 transcripts (splice variants), 275 orthologues, 2 paralogues and is associated with 90 phenotypes. Broad expression in testis (RPKM 16.2), lymph node (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

TCF3 Products (4)

mRNA	Protein	Name
NM_001136139.4	NP_001129611.1	transcription factor E2-alpha isoform E47
NM_001351778.2	NP_001338707.1	transcription factor E2-alpha isoform 3
NM_001351779.2	NP_001338708.1	transcription factor E2-alpha isoform E47
NM_003200.5	NP_003191.1	transcription factor E2-alpha isoform E12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	2503252	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	8759016	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10652346	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	2105528	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	2503252	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14576336	GOA
contributes to E-box binding	IDA IDA: Inferred from direct assay	10775504	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	7933101	GOA
contributes to E-box binding	IPI IPI: Inferred from physical interaction	15044608	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14576336	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10652346	GOA
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	10545951	GOA
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	19801649	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7568177	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	14752053	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10545951	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8759016	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10652346	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	11802795	GOA
enables vitamin D response element binding	IDA IDA: Inferred from direct assay	17426122	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell lineage commitment	IDA IDA: Inferred from direct assay	15030778	GOA
acts upstream of or within immunoglobulin V(D)J recombination	IDA IDA: Inferred from direct assay	16428437	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14576336	GOA
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	11509675	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14752053	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	2105528	GOA
involved in positive regulation of cell cycle	IDA IDA: Inferred from direct assay	11509675	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16428437	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10652346	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	31696227	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	11509675	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	10545951	GOA
located in chromatin	IDA IDA: Inferred from direct assay	21828274	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12435739	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	10652346	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10749989	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	12435739	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	2503252	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor E2-alpha	E2A-HLF fusion transcript protein

TCF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TCF3	P15923	ID3	Homo sapiens	Q02535	Validated Y2H	25416956
Intra	TCF3	P15923	ID3	Homo sapiens	Q02535	Y2H Array	25416956
Intra	TCF3	P15923	ID3	Homo sapiens	Q02535	Y2H Prey Pooling	25416956
Intra	TCF3	P15923	TAL1	Homo sapiens	P17542	Y2H	7568177
Intra	TCF3	P15923	TAL1	Homo sapiens	P17542	Y2H	9824680
Intra	TCF3	P15923	TCAF1	Homo sapiens	Q9Y4C2	Validated Y2H	25416956
Intra	TCF3	P15923	TCAF1	Homo sapiens	Q9Y4C2	Y2H Prey Pooling	25416956
Intra	TCF3	P15923	ASCL1	Homo sapiens	P50553	Y2H	10903890

Cross: Cross-species interaction Intra: Intraspecies interaction

TCF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81475	TCF3 / E2A Antibody (YA1220)	IHC-P	Human
HY-P81475A	TCF3 / E2A Antibody (YA1220)(PBS only)	IHC-P	Human
HY-P84118	TCF3 / E2A Antibody (YA3815)	WB, FC, ELISA	Human
HY-P84118A	TCF3 / E2A Antibody (YA3815)(PBS only)	WB, FC, ELISA	Human
HY-P85127	TCF3 / E2A Antibody (YA4819)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Agammaglobulinemia 8b, Autosomal Recessive	AGM8B Agammaglobulinemia, Autosomal Recessive, Due To Tcf3 Defect
Agammaglobulinemia 8a, Autosomal Dominant	Agammaglobulinemia, Autosomal Dominant, Due To Tcf3 Defect AGM8A Agm8
Agammaglobulinemia, Non-Bruton Type	Autosomal Agammaglobulinemia
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Childhood Leukemia
Agammaglobulinemia 8a
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Saethre-Chotzen Syndrome	SCS Acs3 Acs Iii Chotzen Syndrome Acrocephaly, Skull Asymmetry, And Mild Syndactyly Acrocephalosyndactyly Type 3 Acrocephalosyndactyly, Type Iii Acrocephalosyndactyly Type Iii Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies Auralcephalosyndactyly Acs 3 Acrocephalo-Syndactyly, Type 3 Blepharophimosis,Epicanthus Inversus, And Ptosis 3 Aural Cephalosyndactyly Kurczynski-Casperson Syndrome Acrocephalosyndactyly Iii Dysostosis Craniofacialis With Hypertelorism Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies Sakati Syndrome
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy	B-All With Hyperdiploidy B Lymphoblastic Leukemia Lymphoma With Hyperdiploidy
B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy	B-All With Hypodiploidy Hypodiploid All
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ulnar-Mammary Syndrome	Schinzel Syndrome UMS Pallister Ulnar-Mammary Syndrome Ulnar-Mammary Syndrome Of Pallister
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14306	TCF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14309	TCF7L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183004	NCP26		/	Unkown
HY-RS18501	Tcf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24983	Tcf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TCF3	VGNC	VGNC:58336
Bos taurus	TCF3	VGNC	VGNC:35693
Felis catus	TCF3	VGNC	VGNC:66026
Rattus norvegicus	TCF3	RGD	RGD:620914
Macaca mulatta	TCF3	VGNC	VGNC:78287
Mus musculus	TCF3	MGD	MGI:98510
Others	TCF3	NCBI