ID3 - inhibitor of DNA binding 3 Gene

Homo sapiens

Also known as HEIR-1; bHLHb25

Gene ID: 3399 | Gene type: protein coding

About ID3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,557,926-23,559,501 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 199 orthologues, 3 paralogues and is associated with 33 phenotypes. Broad expression in thyroid (RPKM 81.9), prostate (RPKM 51.6) and 21 other tissues.

Summary

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

ID3 Products(1)

mRNA	Protein	Name
NM_002167.5	NP_002158.3	DNA-binding protein inhibitor ID-3

ID3 Protein Structure

HLH

0
100
119 a.a.

Protein Preferred Names

Protein Names

DNA-binding protein inhibitor ID-3

ID-like protein inhibitor HLH 1R21

Related Diseases

Diseases

Alias

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-143623S	Neo Spiramycin I-d3		/	Unkown
HY-155705	BMP agonist 1		/	Unkown
HY-RS06524	ID3 Human Pre-designed siRNA Set A		/	Unkown
HY-110245	DMH2	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ID3	VGNC	VGNC:41862
Bos taurus	ID3	VGNC	VGNC:30032
Macaca mulatta	ID3	VGNC	VGNC:99974
Rattus norvegicus	ID3	RGD	RGD:2860
Felis catus	ID3	VGNC	VGNC:107562
Mus musculus	ID3	MGD	MGI:96398
Others	ID3	NCBI

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