ID3 - inhibitor of DNA binding 3 Gene

Also Known as HEIR-1; bHLHb25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3399

About ID3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,557,926-23,559,501 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 199 orthologues, 3 paralogues and is associated with 33 phenotypes. Broad expression in thyroid (RPKM 81.9), prostate (RPKM 51.6) and 21 other tissues.

Summary

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with Other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

ID3 Products (1)

mRNA Protein Name
NM_002167.5 NP_002158.3 DNA-binding protein inhibitor ID-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18255255 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14627819 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14627819 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ID3 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (42 - 81)

  • 0
  • 100
  • 119 a.a.
Protein Preferred Names Protein Names

DNA-binding protein inhibitor ID-3

  • ID-like protein inhibitor HLH 1R21

ID3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ID3 Q02535 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra
ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3
Y2H Prey Pooling
25416956
Intra
ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3
Validated Y2H
25416956
Intra
ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3
Y2H Array
25416956
Intra
ID3 Q02535 RAB7A Homo sapiens P51149
Y2H Array
32814053
Intra
ID3 Q02535 RAB7A Homo sapiens P51149
Y2H Pooling
32814053
Intra
ID3 Q02535 RAB7A Homo sapiens P51149
Validated Y2H
32814053
Intra
ID3 Q02535 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
ID3 Q02535 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
ID3 Q02535 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081-3
Y2H Array
31515488
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
ID3 Q02535 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra
ID3 Q02535 GUCD1 Homo sapiens Q96NT3-2
Validated Y2H
32296183
Intra
ID3 Q02535 TCF3 Homo sapiens P15923-3
Y2H Prey Pooling
32296183
Intra
ID3 Q02535 TCF3 Homo sapiens P15923-3
Y2H Array
32296183
Intra
ID3 Q02535 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
ID3 Q02535 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
ID3 Q02535 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra
ID3 Q02535 MYF5 Homo sapiens P13349
Y2H Array
32296183
Intra
ID3 Q02535 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
ID3 Q02535 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
ID3 Q02535 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
ID3 Q02535 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
ID3 Q02535 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
ID3 Q02535 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
ID3 Q02535 FHL2 Homo sapiens Q14192
Y2H
18255255
Intra
ID3 Q02535 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081
Y2H Array
31515488
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081
Validated Y2H
25416956
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081
Y2H Prey Pooling
25416956
Intra
ID3 Q02535 TCF12 Homo sapiens Q99081
Y2H Array
20211142
Intra
ID3 Q02535 C22orf39 Homo sapiens Q6P5X5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ID3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84472 ID3 Antibody (YA4169) IHC-P, FC, ELISA Human, Rat
HY-P84472A ID3 Antibody (YA4169)(PBS only) IHC-P, FC, ELISA Human, Rat

Related Diseases

Diseases Alias
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124697 BMP signaling agonist sb4 Agonist 99.98% Unkown
HY-110245 DMH2 Inducer 99.84% Unkown
HY-155705 BMP agonist 1 / Unkown
HY-RS06524 ID3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143623S Neo Spiramycin I-d3 / Unkown
HY-181116 Anticancer agent 298 / Unkown
HY-RS17523 Id3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23980 Id3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ID3 VGNC VGNC:41862
Bos taurus ID3 VGNC VGNC:30032
Macaca mulatta ID3 VGNC VGNC:99974
Rattus norvegicus ID3 RGD RGD:2860
Felis catus ID3 VGNC VGNC:107562
Mus musculus ID3 MGD MGI:96398
Others ID3 NCBI