Anticancer agent 298
Anticancer agent 298 is a bi-nuclear Cu(II)-hydrazone complexe. Anticancer agent 298 can bind to the CDK-2 active site (PDB ID: 3IG7) via hydrogen bonds with key amino acid residues. Anticancer agent 298 exerts cytotoxic effects against hepatocellular carcinoma cells, and has lower cytotoxicity against normal human embryonic kidney cells. Anticancer agent 298 can be used for the research of hepatocellular carcinoma.
For research use only. We do not sell to patients.
- Formula: C36H54Br2Cu2N6O12
- Molecular Weight:1049.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK2 |
Anticancer agent 298 (Compound 2) potently inhibits hepatocellular carcinoma (HepG-2) cells with an IC50 of 12.27 μM and has an IC50 of 90.16 μM against normal human embryonic kidney (HEK-2) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1049.75
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Formula C36H54Br2Cu2N6O12
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SMILES
CC(C1=C(O[Cu]2([OH]CC)([OH]CC)([OH]CC)Br)C=C(O[Cu]3([OH]CC)([OH]CC)([OH]CC)Br)C(C(C)=[N]3/N=C/C4=CC=CC([N+]([O-])=O)=C4)=C1)=[N]2/N=C/C5=CC([N+]([O-])=O)=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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