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DMH2 is a potent BMP receptor antagonist. DMH2 downregulates the expression of Id1 and Id3 proteins, and inhibits the proliferation and induces cell death of lung cancer cell lines.

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DMH2 Chemical Structure

DMH2 Chemical Structure

CAS No. : 1206711-14-9

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Based on 1 publication(s) in Google Scholar

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Description

DMH2 is a potent BMP receptor antagonist. DMH2 downregulates the expression of Id1 and Id3 proteins, and inhibits the proliferation and induces cell death of lung cancer cell lines[1].

In Vitro

DMH2 decreases expression of Id1 and Id3 and causes growth suppression of three lung cancer cell lines with K-Ras mutation (A549, H157, H727) and three without a K-Ras mutation (H1299, H865, U1752)[1].
The combination of DMH2 and PP2 causes significantly greater reduction in Id1 promoter activity and growth inhibition than either agent alone in the A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DMH2 (0-2 mg/kg, IP, twice daily, for 2 days prior to PH (partial hepatectomy) and for 2 days after PH) increases hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (7-8 weeks, male)[2]
Dosage: 0.5, 1, 2 mg/kg
Administration: IP, twice daily, for 2 days prior to PH and for 2 days after PH (partial hepatectomy)
Result: Increased hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg.
Molecular Weight

451.52

Formula

C27H25N5O2

CAS No.
SMILES

C1(C2=C3N=CC(C4=CC=C(OCCN5CCOCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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DMH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DMH2
Cat. No.:
HY-110245
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