TAL1 - TAL bHLH transcription factor 1, erythroid differentiation factor Gene

Also Known as SCL; TCL5; tal-1; bHLHa17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6886

About TAL1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,216,290-47,232,335 (from NCBI)

This gene has 6 transcripts (splice variants), 212 orthologues, 4 paralogues and is associated with 61 phenotypes. Broad expression in bone marrow (RPKM 7.9), fat (RPKM 4.0) and 18 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022]

TAL1 Products (6)

mRNA	Protein	Name
NM_001287347.2	NP_001274276.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290403.2	NP_001277332.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290404.1	NP_001277333.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290405.1	NP_001277334.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290406.2	NP_001277335.1	T-cell acute lymphocytic leukemia protein 1 isoform 2
NM_003189.5	NP_003180.1	T-cell acute lymphocytic leukemia protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19497860	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	20855495	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15920471	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	16763211	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19497860	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	19497860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7568177	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in basophil differentiation	IEP IEP: Inferred from expression pattern	7678994	GOA
involved in erythrocyte differentiation	IEP IEP: Inferred from expression pattern	7678994	GOA
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	1396592	GOA
involved in megakaryocyte differentiation	IEP IEP: Inferred from expression pattern	7678994	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20028976	GOA
involved in positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of chromatin organization	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	20028976	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	20855495	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20855495	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20855495	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19497860	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15920471	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAL1 Protein Structure

HLH

0
100
200
300
331 a.a.

Protein Preferred Names	Protein Names
T-cell acute lymphocytic leukemia protein 1	T-cell acute lymphocytic leukemia 1

TAL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAL1	P17542	KDM1A	Homo sapiens	O60341-1	Anti Bait CoIP	19497860
Intra	TAL1	P17542	KDM1A	Homo sapiens	O60341-1	Anti Tag CoIP	19497860
Intra	TAL1	P17542	MYB	Homo sapiens	P10242	Anti Bait CoIP	25394790
Cross	TAL1	P17542	Lmo2	Mus musculus	P25801	Y2H	7568177
Cross	TAL1	P17542	Lmo2	Mus musculus	P25801	Pull Down	7568177
Intra	TAL1	P17542	TCF4	Homo sapiens	P15884	Anti Tag CoIP	33961781
Intra	TAL1	P17542	TCF4	Homo sapiens	P15884	Affinity Chrom	35140242
Intra	TAL1	P17542	TCF4	Homo sapiens	P15884	BioID	35140242
Intra	TAL1	P17542	TCF12	Homo sapiens	Q99081	Anti Tag CoIP	33961781
Intra	TAL1	P17542	TCF12	Homo sapiens	Q99081	Anti Bait CoIP	21179004
Intra	TAL1	P17542	TCF12	Homo sapiens	Q99081	BioID	35140242
Intra	TAL1	P17542	TCF12	Homo sapiens	Q99081	Anti Bait CoIP	19497860
Intra	TAL1	P17542	TCF12	Homo sapiens	Q99081	Affinity Chrom	35140242
Intra	TAL1	P17542	TCF12	Homo sapiens	Q99081	Anti Tag CoIP	19497860
Intra	TAL1	P17542	TCF3	Homo sapiens	P15923	BioID	35140242
Intra	TAL1	P17542	TCF3	Homo sapiens	P15923	Affinity Chrom	35140242
Intra	TAL1	P17542	TCF3	Homo sapiens	P15923	Y2H	7568177
Intra	TAL1	P17542	TCF3	Homo sapiens	P15923	Anti Tag CoIP	33961781
Intra	TAL1	P17542	TCF3	Homo sapiens	P15923	Anti Bait CoIP	21179004
Intra	TAL1	P17542	TCF3	Homo sapiens	P15923	Anti Bait CoIP	19497860
Intra	TAL1	P17542	TCF3	Homo sapiens	P15923	Anti Tag CoIP	19497860
Intra	TAL1	P17542	ETS1	Homo sapiens	P14921	Anti Bait CoIP	21179004
Intra	TAL1	P17542	RUNX1	Homo sapiens	Q01196	Anti Tag CoIP	19497860
Intra	TAL1	P17542	RUNX1	Homo sapiens	Q01196	Anti Bait CoIP	21179004

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Childhood T-Cell Acute Lymphoblastic Leukemia	T-Cell Childhood Acute Lymphoblastic Leukemia Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia T-Cell Childhood Acute Lymphocytic Leukemia Childhood T Lymphoblastic Leukemia/Lymphoma
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Lymphoblastic Lymphoma	Lymphoma, Lymphoblastic Lymphoma Lymphoblastic Precursor Cell Lymphoblastic Lymphoma Precursor Cell Lymphoblastic Leukemia Lymphoma
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Erythroleukemia
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136522	S2116		98.05%	Unkown
HY-136523	S2157		98.44%	Unkown
HY-RS14189	TAL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17898	Tal1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24367	Tal1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAL1	MGD	MGI:98480
Rattus norvegicus	TAL1	RGD	RGD:1306748
Bos taurus	TAL1	VGNC	VGNC:35588
Canis familiaris	TAL1	VGNC	VGNC:47096
Others	TAL1	NCBI