CHAF1A - chromatin assembly factor 1 subunit A Gene

Also Known as CAF1; P150; CAF-1; CAF1B; CAF1P150

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10036

About CHAF1A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,402,640-4,450,830 (from NCBI)

This gene has 7 transcripts (splice variants) and 200 orthologues. Broad expression in bone marrow (RPKM 7.4), testis (RPKM 6.1) and 24 other tissues.

Summary

Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]

CHAF1A Products (1)

mRNA Protein Name
NM_005483.3 NP_005474.2 chromatin assembly factor 1 subunit A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromo shadow domain binding IPI
IPI: Inferred from physical interaction
15882967 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16826239 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15805117 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA replication-dependent chromatin assembly IDA
IDA: Inferred from direct assay
8858152 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
Cellular Component GO Annotation Evidence References Source
part of CAF-1 complex IDA
IDA: Inferred from direct assay
8858152 GOA
part of CAF-1 complex IPI
IPI: Inferred from physical interaction
9614144 GOA
located in chromatin IDA
IDA: Inferred from direct assay
9614144 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHAF1A Protein Structure

CAF1-p150_N

CAF1-p150_N: CAF1 complex subunit p150, region binding to PCNA (1 - 229)

CAF-1_p150

CAF-1_p150: Chromatin assembly factor 1 complex p150 subunit, N-terminal (267 - 479)

CAF1A

CAF1A: Chromatin assembly factor 1 subunit A (557 - 634)

CAF1-p150_C2

CAF1-p150_C2: CAF1 complex subunit p150, region binding to CAF1-p60 at C-term (665 - 956)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 956 a.a.
Protein Preferred Names Protein Names

chromatin assembly factor 1 subunit A

  • CAF-1 subunit A

CHAF1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHAF1A Q13111 CHAF1B Homo sapiens Q13112
Anti Tag CoIP
19498464
Intra
CHAF1A Q13111 H3C1 Homo sapiens P68431
Anti Tag CoIP
19498464
Intra
CHAF1A Q13111 CHAF1B Homo sapiens Q13112
Density Sedimentation
19498464
Intra
CHAF1A Q13111 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
CHAF1A Q13111 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 STAT5B Homo sapiens P51692
Y2H Array
32296183
Intra
CHAF1A Q13111 STAT5B Homo sapiens P51692
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
CHAF1A Q13111 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
CHAF1A Q13111 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 NOTO Homo sapiens A8MTQ0
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 NOTO Homo sapiens A8MTQ0
Y2H Array
32296183
Intra
CHAF1A Q13111 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
CHAF1A Q13111 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
CHAF1A Q13111 PCNA Homo sapiens P12004
Pull Down
16826239
Intra
CHAF1A Q13111 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
Intra
CHAF1A Q13111 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
CHAF1A Q13111 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
Intra
CHAF1A Q13111 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra
CHAF1A Q13111 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
CHAF1A Q13111 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
CHAF1A Q13111 SERTAD1 Homo sapiens Q9UHV2
Validated Y2H
32296183
Intra
CHAF1A Q13111 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra
CHAF1A Q13111 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra
CHAF1A Q13111 H3C13 Homo sapiens Q71DI3
Anti Tag CoIP
23075851
Intra
CHAF1A Q13111 CBX5 Homo sapiens P45973
Anti Tag CoIP
19498464
Intra
CHAF1A Q13111 CBX5 Homo sapiens P45973
Density Sedimentation
19498464
Intra
CHAF1A Q13111 MBD1 Homo sapiens Q9UIS9
Pull Down
17066076
Intra
CHAF1A Q13111 GFI1 Homo sapiens Q99684
Anti Bait CoIP
21570500
Cross: Cross-species interaction Intra: Intraspecies interaction

CHAF1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P81743 p150 CAF1 Antibody (YA1488) WB, IHC-P, ICC/IF, FC Human
HY-P81743A p150 CAF1 Antibody (YA1488)(PBS only) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Prostate Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Prostate
Digeorge Syndrome

  • Chromosome 22q11.2 Deletion Syndrome

  • DGS

  • Hypoplasia Of Thymus And Parathyroids

  • Third And Fourth Pharyngeal Pouch Syndrome

  • 22q11.2 Deletion Syndrome

  • Digeorge Sequence

  • Digeorge'S Syndrome

  • Pharyngeal Pouch Syndrome

  • Di-George Syndrome

  • Shprintzen Syndrome
Alpha Thalassemia-Intellectual Disability Syndrome Type 1

  • Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type

  • Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16

  • Atr Syndrome Linked To Chromosome 16

  • Atr Syndrome, Deletion Type

  • Atr-16 Syndrome

  • Alpha Thalassemia-Retardation Syndrome

  • Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type

  • Alpha-Thalassemia/Mental Retardation Syndrome, Type 1

  • Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02594 CHAF1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21836 Chaf1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28352 Chaf1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CHAF1A RGD RGD:1590865
Canis familiaris CHAF1A VGNC VGNC:39189
Bos taurus CHAF1A VGNC VGNC:27266
Felis catus CHAF1A VGNC VGNC:60835
Macaca mulatta CHAF1A VGNC VGNC:71024
Mus musculus CHAF1A MGD MGI:1351331
Others CHAF1A NCBI