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FOXD2 - forkhead box D2 Gene

Also Known as FKHL17; FREAC9; FREAC-9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2306

About FOXD2

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,438,044-47,440,691 (from NCBI)

This gene has 1 transcript (splice variant), 128 orthologues and 42 paralogues.

Summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

FOXD2 Products (1)

mRNA	Protein	Name
NM_004474.4	NP_004465.3	forkhead box protein D2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12621056	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12621056	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXD2 Protein Structure

Forkhead

0
100
200
300
400
495 a.a.

Protein Preferred Names	Protein Names
forkhead box protein D2	forkhead, drosophila, homolog-like 17

FOXD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOXD2	O60548	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	FOXD2	O60548	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	FOXD2	O60548	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	FOXD2	O60548	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	FOXD2	O60548	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	FOXD2	O60548	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	FOXD2	O60548	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP15-1	Homo sapiens	Q3LI76	Validated Y2H	32296183
Intra	FOXD2	O60548	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP19-2	Homo sapiens	Q3LHN2	Validated Y2H	32296183
Intra	FOXD2	O60548	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Array	32296183
Intra	FOXD2	O60548	NOTO	Homo sapiens	A8MTQ0	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	NOTO	Homo sapiens	A8MTQ0	Y2H Array	32296183
Intra	FOXD2	O60548	FOXH1	Homo sapiens	O75593	Y2H Array	32296183
Intra	FOXD2	O60548	FOXH1	Homo sapiens	O75593	Validated Y2H	32296183
Intra	FOXD2	O60548	FOXH1	Homo sapiens	O75593	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	KRTAP21-2	Homo sapiens	Q3LI59	Validated Y2H	32296183
Intra	FOXD2	O60548	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	FOXD2	O60548	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	FOXD2	O60548	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	FOXD2	O60548	SPMIP9	Homo sapiens	Q96LM6	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	SPMIP9	Homo sapiens	Q96LM6	Validated Y2H	32296183
Intra	FOXD2	O60548	SPMIP9	Homo sapiens	Q96LM6	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	32296183
Intra	FOXD2	O60548	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183
Intra	FOXD2	O60548	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	POU2AF1	Homo sapiens	Q16633	Validated Y2H	32296183
Intra	FOXD2	O60548	POU2AF1	Homo sapiens	Q16633	Y2H Array	32296183
Intra	FOXD2	O60548	POU2AF1	Homo sapiens	Q16633	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	FOXD2	O60548	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	FOXD2	O60548	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Thyroid Gland Mucoepidermoid Carcinoma	Mucoepidermoid Thyroid Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05044	FOXD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20928	Foxd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27445	Foxd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FOXD2	VGNC	VGNC:107543
Macaca mulatta	FOXD2	VGNC	VGNC:72695
Mus musculus	FOXD2	MGD	MGI:1347471
Bos taurus	FOXD2	VGNC	VGNC:55192
Rattus norvegicus	FOXD2	RGD	RGD:1304642
Others	FOXD2	NCBI