country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

IP6K3 - inositol hexakisphosphate kinase 3 Gene

Also Known as IHPK3; INSP6K3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117283

About IP6K3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,721,662-33,762,145 (from NCBI)

This gene has 3 transcripts (splice variants), 138 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 4.4), heart (RPKM 3.1) and 14 other tissues.

Summary

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

IP6K3 Products (2)

mRNA	Protein	Name
NM_001142883.2	NP_001136355.1	inositol hexakisphosphate kinase 3
NM_054111.5	NP_473452.2	inositol hexakisphosphate kinase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables inositol hexakisphosphate 6-kinase activity	IDA IDA: Inferred from direct assay	11502751	GOA
enables inositol hexakisphosphate kinase activity	IDA IDA: Inferred from direct assay	11502751	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within inositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	11502751	GOA
involved in phosphatidylinositol metabolic process	IDA IDA: Inferred from direct assay	11502751	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11502751	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11502751	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IP6K3 Protein Structure

IPK

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
inositol hexakisphosphate kinase 3	ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IP6K3	Q96PC2	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	IP6K3	Q96PC2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	IP6K3	Q96PC2	NOTO	Homo sapiens	A8MTQ0	Y2H Array	32296183
Intra	IP6K3	Q96PC2	NOTO	Homo sapiens	A8MTQ0	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	IP6K3	Q96PC2	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	MED4	Homo sapiens	Q9NPJ6	Y2H Array	32296183
Intra	IP6K3	Q96PC2	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	32296183
Intra	IP6K3	Q96PC2	POLR2E	Homo sapiens	P19388	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	POLR2E	Homo sapiens	P19388	Y2H Array	32296183
Intra	IP6K3	Q96PC2	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	IP6K3	Q96PC2	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	IP6K3	Q96PC2	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	IP6K3	Q96PC2	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	IP6K3	Q96PC2	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
Intra	IP6K3	Q96PC2	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	IP6K3	Q96PC2	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	IP6K3	Q96PC2	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	IP6K3	Q96PC2	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153530	LI-2242	Inhibitor	98.83%	Unkown
HY-171099	SC-919	Inhibitor	98.68%	Unkown
HY-122706A	IP6K2-IN-2	Inhibitor	99.70%	Unkown
HY-161032	IP6K2-IN-1	Inhibitor	99.47%	Unkown
HY-RS06863	IP6K3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IP6K3	VGNC	VGNC:107290
Mus musculus	IP6K3	MGD	MGI:3045325
Felis catus	IP6K3	VGNC	VGNC:102444
Canis familiaris	IP6K3	VGNC	VGNC:42063
Macaca mulatta	IP6K3	VGNC	VGNC:81083
Rattus norvegicus	IP6K3	RGD	RGD:1584104
Others	IP6K3	NCBI