IP6K2-IN-1 

IP6K2-IN-1 is a selective flavonoid-based IP6K2 inhibitor with an IC₅₀ value of 0.55 μM^[1]. IP6K2-IN-1 shows higher inhibitory potency against IP6K2 than IP6K1 and IP6K3. IP6K2-IN-1 can be utilised as a hit compound for further structural modifications of IP6K2 inhibitors^[1].

IP6K2-IN-1 (Compound 20s) shows IC₅₀ value of 2.87 µM against IP6K1 resulting 5.22-fold IC₅₀ ratio of IP6K1/IP6K2 and IC₅₀ value of 3.56 µM against IP6K3, resulting 6.47-fold IC₅₀ ratio of IP6K3/IP6K2^[1].
IP6K2-IN-1 failed to reduce IP7 levels in HCT116 cells, indicating low cell permeability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

314.25

C₁₆H₁₀O₇

2926679-10-7

Solid

Yellow to brown

OC1=C(O)C=C(C(C(O)=C(C2=CC(C(O)=O)=CC=C2)O3)=O)C3=C1

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Myunghwan Ahn, et al. Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2193866.  [Content Brief]