INK4C-IN-2
Based on 1 publication(s) in Google Scholar
INK4C-IN-2 is a p18INK4C inhibitor. NK4C-IN-2 promotes hematopoietic stem cells (HSCs) division by inhibiting INK4C and activating CDK4/6, with an ED50 of 5.21 nM. INK4C-IN-2 shows no cytotoxic to normal 32D cells, HSCs, leukemia cell lines and myeloma cell lines.
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 6314-70-1
- Formula: C13H17NO4S
- Molecular Weight:283.34
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) INK4C-IN-2
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Biological Activity
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CDK4 |
CDK6 |
INK4C-IN-2 (Compound 40) (0.01-1 μM, 7 days) promotes human HSC expansion ex vivo[1].
INK4C-IN-2 (14 days) increases number of Phenotypic Long Term (LT)-HSCs[1].
INK4C-IN-2 (5 days) stimulates HSCs division by inhibiting INK4C[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human cord blood CD34+ cells
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Concentration:0.01, 0.1, 1 μM
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Incubation Time:7 days
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Result:Increased the absolute number of CD34+ and CD49f+ cells by more than 30% when the concentration at 200 nM.
Increased absolute CD34+ CD49f+ cell number at 0.01-1 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (6-8 weeks old)[1].
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Dosage:20 μM
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Administration:Co-transplanted into mice via tail-vein injection, followed by a 16 week engraftment period
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Result:Increased 5.93-fold cells in the engraftment.
Chemical Information
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CAS No. 6314-70-1
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Appearance Solid
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Molecular Weight 283.34
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Formula C13H17NO4S
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(S(=O)(NC2CCCCC2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability. [Abstract]2019 Mar 20;10(4):271. PMID: 30894510
Solvent & Solubility
DMSO : 250 mg/mL (882.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5293 mL | 17.6466 mL | 35.2933 mL | 88.2332 mL |
| 5 mM | 0.7059 mL | 3.5293 mL | 7.0587 mL | 17.6466 mL | |
| 10 mM | 0.3529 mL | 1.7647 mL | 3.5293 mL | 8.8233 mL | |
| 15 mM | 0.2353 mL | 1.1764 mL | 2.3529 mL | 5.8822 mL | |
| 20 mM | 0.1765 mL | 0.8823 mL | 1.7647 mL | 4.4117 mL | |
| 25 mM | 0.1412 mL | 0.7059 mL | 1.4117 mL | 3.5293 mL | |
| 30 mM | 0.1176 mL | 0.5882 mL | 1.1764 mL | 2.9411 mL | |
| 40 mM | 0.0882 mL | 0.4412 mL | 0.8823 mL | 2.2058 mL | |
| 50 mM | 0.0706 mL | 0.3529 mL | 0.7059 mL | 1.7647 mL | |
| 60 mM | 0.0588 mL | 0.2941 mL | 0.5882 mL | 1.4706 mL | |
| 80 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1029 mL | |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.8823 mL |
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