1. Cell Cycle/DNA Damage
  2. CDK
  3. Cimpuciclib tosylate

Cimpuciclib tosylate 

Cat. No.: HY-112243A Purity: 99.16%
Handling Instructions

Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.

For research use only. We do not sell to patients.

Cimpuciclib tosylate Chemical Structure

Cimpuciclib tosylate Chemical Structure

CAS No. : 2408872-84-2

Size Price Stock Quantity
5 mg USD 780 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4050 In-stock
Estimated Time of Arrival: December 31
100 mg USD 6500 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cimpuciclib tosylate:

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Description

Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1].

IC50 & Target[1]

CDK4

0.49 nM (IC50)

CDK6

9.56 nM (IC50)

In Vitro

Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Colo205 cells
Concentration: 0-500 nM approximately
Incubation Time: 6 days
Result: Inhibited cell proliferation with an IC50 value of 141.2 nM.
In Vivo

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colo205 tumor-bearing mice[1]
Dosage: 50 mg/kg, twice a week
Administration: Oral gavage
Result: Inhibited tumor growth by 93.63%
Animal Model: Rats, colo205 tumor-bearing mice[1]
Dosage: 5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration: Oral administration
Result: Pharmacokinetic profile of Cimpuciclib (example 63).
dose Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mL•h) t1/2 (h)
5 mg/kg (rats) 559.7 6 5414 2.4
50 mg/kg (mice) 7960 1 136782 14.8
Molecular Weight

714.85

Formula

C37H43FN8O4S

CAS No.
SMILES

O=C(N1CCC(CC1)NC2CC2)C3=CC=C(NC4=NC(C5=CC6=C(N=C(C)N6C(C)C)C=C5)=C(F)C=N4)N=C3C.O=S(O)(C7=CC=C(C)C=C7)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (279.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3989 mL 6.9945 mL 13.9889 mL
5 mM 0.2798 mL 1.3989 mL 2.7978 mL
10 mM 0.1399 mL 0.6994 mL 1.3989 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Product Name:
Cimpuciclib tosylate
Cat. No.:
HY-112243A
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