1. Cell Cycle/DNA Damage
  2. CDK
  3. Cimpuciclib tosylate

Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.

For research use only. We do not sell to patients.

Cimpuciclib tosylate Chemical Structure

Cimpuciclib tosylate Chemical Structure

CAS No. : 2408872-84-2

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1].

IC50 & Target[1]

CDK4

0.49 nM (IC50)

CDK6

9.56 nM (IC50)

In Vitro

Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Colo205 cells
Concentration: 0-500 nM approximately
Incubation Time: 6 days
Result: Inhibited cell proliferation with an IC50 value of 141.2 nM.
In Vivo

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colo205 tumor-bearing mice[1]
Dosage: 50 mg/kg, twice a week
Administration: Oral gavage
Result: Inhibited tumor growth by 93.63%
Animal Model: Rats, colo205 tumor-bearing mice[1]
Dosage: 5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration: Oral administration
Result: Pharmacokinetic profile of Cimpuciclib (example 63).
dose Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mL•h) t1/2 (h)
5 mg/kg (rats) 559.7 6 5414 2.4
50 mg/kg (mice) 7960 1 136782 14.8
Molecular Weight

714.85

Formula

C37H43FN8O4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCC(CC1)NC2CC2)C3=CC=C(NC4=NC(C5=CC6=C(N=C(C)N6C(C)C)C=C5)=C(F)C=N4)N=C3C.O=S(O)(C7=CC=C(C)C=C7)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (279.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3989 mL 6.9945 mL 13.9889 mL
5 mM 0.2798 mL 1.3989 mL 2.7978 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3989 mL 6.9945 mL 13.9889 mL 34.9724 mL
5 mM 0.2798 mL 1.3989 mL 2.7978 mL 6.9945 mL
10 mM 0.1399 mL 0.6994 mL 1.3989 mL 3.4972 mL
15 mM 0.0933 mL 0.4663 mL 0.9326 mL 2.3315 mL
20 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7486 mL
25 mM 0.0560 mL 0.2798 mL 0.5596 mL 1.3989 mL
30 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
40 mM 0.0350 mL 0.1749 mL 0.3497 mL 0.8743 mL
50 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6994 mL
60 mM 0.0233 mL 0.1166 mL 0.2331 mL 0.5829 mL
80 mM 0.0175 mL 0.0874 mL 0.1749 mL 0.4372 mL
100 mM 0.0140 mL 0.0699 mL 0.1399 mL 0.3497 mL
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Cimpuciclib tosylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cimpuciclib tosylate
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