CDK4/6-IN-16
CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer.
For research use only. We do not sell to patients.
- CAS No.: 1169694-98-7
- Formula: C27H33FN8O
- Molecular Weight:504.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
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CDK4 13 nM (IC50) |
CDK6 |
Chemical Information
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CAS No. 1169694-98-7
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Molecular Weight 504.60
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Formula C27H33FN8O
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SMILES
FC1=NC=CC2=C1N(C3CCCC3)C4=C2C=NC(NC5=NC=C(N6CCC(CC6)N(CCO)C)C=C5)=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)