Pomalidomide-d3
Based on 1 Customer Validation
Pomalidomide-d3 (CC-4047-d3) is the deuterated-labeled Pomalidomide (HY-10984). Pomalidomide (CC-4047) is an immunomodulatory agent. Pomalidomide downregulates TNF-alpha, IL-1, IL-11, and IL-12, upregulates IL-2, IL-5, and IL-10, and costimulates T cells. Pomalidomide inhibits the proliferation of T regulatory cells by reducing FOXP3/OX-40 expression and IL-2-mediated expansion. Pomalidomide inhibits CDK2/4/6 and p21WAF-1, causing cell cycle arrest. Pomalidomide can be used in research on myelofibrosis-associated anemia, multiple myeloma, and colorectal cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.0%
- CAS. Nr.: 2093128-28-8
- Formel: C13H8D3N3O4
- Molecular Weight:276.27
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
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IL-1 |
TNF-alpha |
IL-12 |
IL-2 |
IL-5 |
IL-10 |
IL-11 |
FOXP3 |
CDK2 |
OX-40 |
CDK4 |
CDK6 |
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 2093128-28-8
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Unlabeled CAS 19171-19-8
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Appearance Solid
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Molecular Weight 276.27
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Formel C13H8D3N3O4
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Color Light yellow to yellow
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SMILES
O=C1N(C2C(NC(CC2)=O)=O)C(C3=C(N)C([2H])=C([2H])C([2H])=C31)=O
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Synonyms
CC-4047-d3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (180.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6196 mL | 18.0982 mL | 36.1965 mL | 90.4912 mL |
| 5 mM | 0.7239 mL | 3.6196 mL | 7.2393 mL | 18.0982 mL | |
| 10 mM | 0.3620 mL | 1.8098 mL | 3.6196 mL | 9.0491 mL | |
| 15 mM | 0.2413 mL | 1.2065 mL | 2.4131 mL | 6.0327 mL | |
| 20 mM | 0.1810 mL | 0.9049 mL | 1.8098 mL | 4.5246 mL | |
| 25 mM | 0.1448 mL | 0.7239 mL | 1.4479 mL | 3.6196 mL | |
| 30 mM | 0.1207 mL | 0.6033 mL | 1.2065 mL | 3.0164 mL | |
| 40 mM | 0.0905 mL | 0.4525 mL | 0.9049 mL | 2.2623 mL | |
| 50 mM | 0.0724 mL | 0.3620 mL | 0.7239 mL | 1.8098 mL | |
| 60 mM | 0.0603 mL | 0.3016 mL | 0.6033 mL | 1.5082 mL | |
| 80 mM | 0.0452 mL | 0.2262 mL | 0.4525 mL | 1.1311 mL | |
| 100 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9049 mL |
Pomalidomide-d3 Related Classifications
HY-10984S1 Related Classifications
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Keywords
- Pomalidomide-d3
- 2093128-28-8
- CC-4047-d3
- Isotope-Labeled Compounds
- TNF Receptor
- Interleukin Related
- FOXP
- Orexin Receptor (OX Receptor)
- CDK
- Tumor Necrosis Factor Receptor
- TNFR
- IL
- Forkhead Box P Protein
- Hypocretin Receptor
- HCRT Receptor
- Cyclin dependent kinase
- FOXP3
- IL-1
- IL-10
- IL-11
- IL-12
- IL-2
- IL-5
- T cells
- T-regulatory cell
- TNF-alpha
- Inhibitor
- inhibitor
- inhibit