1. Cell Cycle/DNA Damage
  2. CDK
  3. MC180295

MC180295 (Synonyms: (rel)-MC180295)

Cat. No.: HY-119940 Purity: 98.47%
Handling Instructions

MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect.

For research use only. We do not sell to patients.

MC180295 Chemical Structure

MC180295 Chemical Structure

CAS No. : 2237942-08-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect[1].

IC50 & Target

CDK9- Cyclin T1

5 nM (IC50)

CDK4-Cyclin D

112 nM (IC50)

CDK1-Cyclin B

138 nM (IC50)

cdk5-p35

159 nM (IC50)

cdk5-p25

186 nM (IC50)

cdk2-cyclin A

233 nM (IC50)

cdk2-cyclin E

367 nM (IC50)

CDK3-Cyclin E

399 nM (IC50)

CDK7-CycH/MAT1

555 nM (IC50)

cdk6-cyclin D3

712 nM (IC50)

In Vitro

MC180295 is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs, such as CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), CDK5-P25 (IC50, 186 nM), CDK6-Cyclin D3 (IC50, 712 nM), and CDK7-CycH/MAT1 (IC50, 555 nM). MC180295 also inhibits GSK-3α and GSK-3β[1].
MC180295 (500 nM) reactivates epigenetically silenced genes by targeting CDK9 without affecting DNA methylation[1].
MC180295 (0.1 μM) inhibits the proliferation in cancer cells[1].

In Vivo

MC180295 (20 mg/kg, i.p., qod) inhibits significant anti-tumor activity in mice bearing SW48 cells, shows no inhibitory activity against human T cell growth in vivo[1].

Storage

4°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (279.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7901 mL 13.9505 mL 27.9010 mL
5 mM 0.5580 mL 2.7901 mL 5.5802 mL
10 mM 0.2790 mL 1.3951 mL 2.7901 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

358.41

Formula

C₁₇H₁₈N₄O₃S

CAS No.

2237942-08-2

SMILES

NC1=C(C(C2=CC=CC=C2[N+]([O-])=O)=O)SC(N[[email protected]@H]3[[email protected]](C4)CC[[email protected]]4C3)=N1

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MC180295
Cat. No.:
HY-119940
Quantity:

MC180295

Cat. No.: HY-119940